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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STRN4

Summary for STRN4

Gene information	Gene symbol	STRN4
	Ensembl ID	ENSG00000090372
	Entrez ID	29888
	Gene name	striatin 4
	Synonyms	PPP2R6C\|ZIN
	Gene type	protein_coding
	UniProtAcc	Q9NRL3

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Dataset with differentially expressed gene: STRN4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.370204	0.00e+00

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Expression of STRN4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STRN4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STRN4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STRN4	hsa-miR-1185-1-3p	94.3207	NM_001039877
STRN4	hsa-let-7f-2-3p	94.3207	NM_001039877
STRN4	hsa-miR-1185-2-3p	94.3207	NM_001039877
STRN4	hsa-miR-128-3p	93.2214	NM_001039877
STRN4	hsa-miR-216a-3p	93.2214	NM_001039877
STRN4	hsa-miR-3681-3p	93.2214	NM_001039877
STRN4	hsa-miR-4693-3p	90.0294	NM_013403
STRN4	hsa-miR-3145-5p	89.8557	NM_013403
STRN4	hsa-miR-4441	88.291	NM_001039877
STRN4	hsa-miR-5586-3p	85.816	NM_013403
STRN4	hsa-miR-23c	85.3063	NM_001039877
STRN4	hsa-miR-23a-3p	85.3063	NM_001039877
STRN4	hsa-miR-23b-3p	85.3063	NM_001039877
STRN4	hsa-miR-4270	84.8541	NM_001039877
STRN4	hsa-miR-6852-5p	84.5989	NM_013403
STRN4	hsa-miR-6873-5p	84.3816	NM_013403
STRN4	hsa-miR-3121-3p	83.8287	NM_001039877
STRN4	hsa-miR-6739-5p	83.007	NM_013403
STRN4	hsa-miR-6733-5p	83.007	NM_013403
STRN4	hsa-miR-12115	82.9009	NM_013403
STRN4	hsa-miR-3153	82.5049	NM_013403
STRN4	hsa-miR-29b-3p	80.9258	NM_001039877
STRN4	hsa-miR-29a-3p	80.9258	NM_001039877
STRN4	hsa-miR-29c-3p	80.9258	NM_001039877
STRN4	hsa-miR-377-3p	80.7575	NM_001039877

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Motifs and transcription factors (TFs) regulating STRN4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STRN4	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
STRN4	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
STRN4	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
STRN4	transfac_pro__M00652	NRF1 (directAnnotation).
STRN4	transfac_pro__M04866	HDAC2 (directAnnotation).
STRN4	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."