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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STRN3

Summary for STRN3

Gene information	Gene symbol	STRN3
	Ensembl ID	ENSG00000196792
	Entrez ID	29966
	Gene name	striatin 3
	Synonyms	PPP2R6B\|S/G2NA\|SG2NA
	Gene type	protein_coding
	UniProtAcc	Q13033

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Dataset with differentially expressed gene: STRN3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.871966	0.00e+00

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Expression of STRN3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STRN3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STRN3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STRN3	hsa-miR-548x-3p	99.2189	NM_001083893
STRN3	hsa-miR-548aj-3p	99.2189	NM_001083893
STRN3	hsa-miR-548aq-3p	98.8721	NM_001083893
STRN3	hsa-miR-548am-3p	98.8721	NM_001083893
STRN3	hsa-miR-548j-3p	98.8721	NM_001083893
STRN3	hsa-miR-548ah-3p	98.8721	NM_001083893
STRN3	hsa-miR-548ae-3p	98.8721	NM_001083893
STRN3	hsa-miR-4272	98.7421	NM_001083893
STRN3	hsa-miR-10527-5p	98.7032	NM_001083893
STRN3	hsa-miR-586	97.7623	NM_001083893
STRN3	hsa-miR-3185	96.8788	NM_001083893
STRN3	hsa-miR-1468-3p	95.9168	NM_001083893
STRN3	hsa-miR-3163	95.8832	NM_001083893
STRN3	hsa-miR-421	95.3596	NM_001083893
STRN3	hsa-miR-585-5p	95.2422	NM_001083893
STRN3	hsa-miR-384	95.0308	NM_001083893
STRN3	hsa-miR-548p	93.8378	NM_001083893
STRN3	hsa-miR-7844-5p	93.5225	NM_001083893
STRN3	hsa-miR-150-3p	93.4906	NM_001083893
STRN3	hsa-miR-7975	93.2837	NM_001083893
STRN3	hsa-miR-3663-3p	92.9242	NM_001083893
STRN3	hsa-miR-143-3p	92.73	NM_001083893
STRN3	hsa-miR-6088	92.73	NM_001083893
STRN3	hsa-miR-4770	92.73	NM_001083893
STRN3	hsa-miR-92a-3p	92.6261	NM_001083893
STRN3	hsa-miR-92b-3p	92.6261	NM_001083893
STRN3	hsa-miR-32-5p	92.6261	NM_001083893
STRN3	hsa-miR-449a	92.3998	NM_001083893
STRN3	hsa-miR-34a-5p	92.3998	NM_001083893
STRN3	hsa-miR-142-3p	92.2747	NM_001083893
STRN3	hsa-miR-4433a-5p	92.2116	NM_001083893
STRN3	hsa-miR-6505-5p	92.1639	NM_001083893
STRN3	hsa-miR-10524-5p	91.9963	NM_001083893
STRN3	hsa-miR-4325	91.7703	NM_001083893
STRN3	hsa-miR-5087	91.6816	NM_001083893
STRN3	hsa-miR-101-3p	91.6095	NM_001083893
STRN3	hsa-miR-144-3p	91.6095	NM_001083893
STRN3	hsa-miR-6508-5p	90.9166	NM_001083893
STRN3	hsa-miR-8067	90.9166	NM_001083893
STRN3	hsa-miR-5701	90.8123	NM_001083893
STRN3	hsa-miR-367-3p	90.8019	NM_001083893
STRN3	hsa-miR-363-3p	90.8019	NM_001083893
STRN3	hsa-miR-25-3p	90.8019	NM_001083893
STRN3	hsa-miR-7161-5p	90.4659	NM_001083893
STRN3	hsa-miR-5011-5p	90.2479	NM_001083893
STRN3	hsa-miR-7159-5p	90.2121	NM_001083893
STRN3	hsa-miR-9-3p	90.1384	NM_001083893
STRN3	hsa-miR-383-5p	89.7938	NM_001083893
STRN3	hsa-miR-449b-5p	89.6429	NM_001083893
STRN3	hsa-miR-34c-5p	89.6429	NM_001083893

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Motifs and transcription factors (TFs) regulating STRN3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."