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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STRBP

Summary for STRBP

Gene information	Gene symbol	STRBP
	Ensembl ID	ENSG00000165209
	Entrez ID	55342
	Gene name	spermatid perinuclear RNA binding protein
	Synonyms	FLJ11307\|ILF3L\|SPNR
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: STRBP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.418693	3.21e-28
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.289328	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.308843	6.13e-16
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.353377	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.472913	0.00e+00

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Expression of STRBP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STRBP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STRBP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STRBP	hsa-miR-520d-5p	99.8694	NM_001171137
STRBP	hsa-miR-524-5p	99.8694	NM_001171137
STRBP	hsa-miR-3529-3p	99.1977	NM_001171137
STRBP	hsa-miR-1297	98.8721	NM_001171137
STRBP	hsa-miR-539-5p	98.6263	NM_001171137
STRBP	hsa-miR-26a-5p	98.3011	NM_001171137
STRBP	hsa-miR-26b-5p	98.3011	NM_001171137
STRBP	hsa-miR-135b-5p	98.0803	NM_001171137
STRBP	hsa-miR-135a-5p	98.0803	NM_001171137
STRBP	hsa-miR-4465	97.9778	NM_001171137
STRBP	hsa-miR-3919	97.7057	NM_001171137
STRBP	hsa-miR-12136	96.4194	NM_001171137
STRBP	hsa-miR-4775	96.3775	NM_001171137
STRBP	hsa-miR-4782-3p	95.9548	NM_001171137
STRBP	hsa-miR-6766-3p	95.9548	NM_001171137
STRBP	hsa-miR-219a-5p	95.9548	NM_001171137
STRBP	hsa-miR-6815-3p	95.0733	NM_001171137
STRBP	hsa-miR-3119	94.6602	NM_001171137
STRBP	hsa-miR-8485	94.4486	NM_001171137
STRBP	hsa-miR-202-3p	94.4167	NM_001171137
STRBP	hsa-miR-6856-3p	93.5666	NM_001171137
STRBP	hsa-miR-205-5p	92.6872	NM_001171137
STRBP	hsa-miR-543	92.6615	NM_001171137
STRBP	hsa-miR-335-3p	91.7265	NM_001171137
STRBP	hsa-miR-6809-3p	91.1352	NM_001171137
STRBP	hsa-miR-603	90.4229	NM_001171137
STRBP	hsa-miR-4668-3p	89.761	NM_001171137
STRBP	hsa-miR-137-3p	89.7243	NM_001171137
STRBP	hsa-miR-4492	89.5472	NM_001171137
STRBP	hsa-miR-3941	89.3974	NM_001171137
STRBP	hsa-miR-4500	88.9529	NM_001171137
STRBP	hsa-miR-551b-5p	88.8157	NM_001171137
STRBP	hsa-miR-548s	88.5359	NM_001171137
STRBP	hsa-miR-4719	88.0325	NM_001171137
STRBP	hsa-miR-2053	87.8679	NM_001171137
STRBP	hsa-miR-3925-5p	87.8207	NM_001171137
STRBP	hsa-miR-4251	87.4129	NM_001171137
STRBP	hsa-miR-548x-3p	87.2064	NM_001171137
STRBP	hsa-miR-548aj-3p	87.2064	NM_001171137
STRBP	hsa-miR-1303	87.0292	NM_001171137
STRBP	hsa-miR-4690-3p	87.0169	NM_001171137
STRBP	hsa-miR-5685	87.0169	NM_001171137
STRBP	hsa-miR-3158-3p	86.9084	NM_001171137
STRBP	hsa-miR-5001-5p	86.689	NM_001171137
STRBP	hsa-miR-4498	86.689	NM_001171137
STRBP	hsa-miR-762	86.689	NM_001171137
STRBP	hsa-miR-5680	86.6359	NM_001171137
STRBP	hsa-miR-124-5p	86.488	NM_001171137
STRBP	hsa-let-7i-5p	85.9958	NM_001171137
STRBP	hsa-let-7a-5p	85.9958	NM_001171137

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Motifs and transcription factors (TFs) regulating STRBP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STRBP	metacluster_7.13	ZFX (directAnnotation).
STRBP	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
STRBP	metacluster_151.2	ZNF23 (directAnnotation).
STRBP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
STRBP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
STRBP	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
STRBP	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
STRBP	hdpi__ETV4	ETV4 (directAnnotation).
STRBP	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
STRBP	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
STRBP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
STRBP	cisbp__M08198	ELF1 (directAnnotation).
STRBP	transfac_pro__M06331	ZNF343 (directAnnotation).
STRBP	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
STRBP	jaspar__MA0748.2	YY2 (directAnnotation).
STRBP	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
STRBP	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
STRBP	transfac_pro__M12697	ZNF142 (directAnnotation).
STRBP	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
STRBP	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
STRBP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
STRBP	cisbp__M07938	E2F1 (directAnnotation).
STRBP	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
STRBP	jaspar__MA1122.1	TFDP1 (directAnnotation).
STRBP	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
STRBP	transfac_pro__M01175	ZBTB7B (directAnnotation).
STRBP	metacluster_3.14	WT1; WT1 (directAnnotation).
STRBP	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
STRBP	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
STRBP	transfac_pro__M01253	CNOT3 (directAnnotation).
STRBP	transfac_pro__M02090	E2F4 (directAnnotation).
STRBP	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
STRBP	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
STRBP	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
STRBP	transfac_pro__M01303	SP1 (directAnnotation).
STRBP	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
STRBP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
STRBP	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
STRBP	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
STRBP	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
STRBP	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
STRBP	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
STRBP	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
STRBP	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
STRBP	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
STRBP	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
STRBP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
STRBP	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
STRBP	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
STRBP	jaspar__MA0597.2	THAP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."