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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STRADB

Summary for STRADB

Gene information	Gene symbol	STRADB
	Ensembl ID	ENSG00000082146
	Entrez ID	55437
	Gene name	STE20 related adaptor beta
	Synonyms	ALS2CR2\|CALS-21\|ILPIP\|ILPIPA\|PAPK
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: STRADB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	0.344387	1.54e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.412548	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.461932	0.00e+00

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Expression of STRADB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STRADB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STRADB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STRADB	hsa-miR-1297	99.881	NM_001206864
STRADB	hsa-miR-26a-5p	99.7841	NM_001206864
STRADB	hsa-miR-26b-5p	99.7841	NM_001206864
STRADB	hsa-miR-4465	99.699	NM_001206864
STRADB	hsa-miR-24-3p	99.3972	NM_001206864
STRADB	hsa-miR-3612	99.1759	NM_001206864
STRADB	hsa-miR-650	99.1759	NM_001206864
STRADB	hsa-miR-5697	98.8273	NM_001206864
STRADB	hsa-miR-149-5p	97.3811	NM_001206864
STRADB	hsa-miR-498-5p	94.5771	NM_001206864
STRADB	hsa-miR-195-5p	94.0757	NM_001206864
STRADB	hsa-miR-424-5p	93.9714	NM_001206864
STRADB	hsa-miR-16-5p	93.9714	NM_001206864
STRADB	hsa-miR-497-5p	93.9714	NM_001206864
STRADB	hsa-miR-15a-5p	93.9714	NM_001206864
STRADB	hsa-miR-15b-5p	93.9714	NM_001206864
STRADB	hsa-miR-6838-5p	93.9714	NM_001206864
STRADB	hsa-miR-12122	91.7412	NM_001206864
STRADB	hsa-miR-1305	90.7148	NM_001206864
STRADB	hsa-miR-140-5p	90.5392	NM_001206864
STRADB	hsa-miR-3192-5p	89.5068	NM_018571
STRADB	hsa-miR-3943	88.953	NM_018571
STRADB	hsa-miR-2467-5p	88.9324	NM_001206864
STRADB	hsa-miR-32-3p	88.0102	NM_018571
STRADB	hsa-miR-4742-3p	87.68	NM_018571
STRADB	hsa-miR-3180-5p	86.6325	NM_018571
STRADB	hsa-miR-7977	85.7557	NM_001206864
STRADB	hsa-miR-548e-5p	85.5972	NM_001206864
STRADB	hsa-miR-1825	84.3953	NM_001206864
STRADB	hsa-miR-3925-3p	83.3586	NM_001206864
STRADB	hsa-miR-7705	82.2871	NM_018571
STRADB	hsa-miR-429	82.2264	NM_018571
STRADB	hsa-miR-200b-3p	82.2264	NM_018571
STRADB	hsa-miR-200c-3p	82.2264	NM_018571
STRADB	hsa-miR-651-5p	81.6986	NM_018571
STRADB	hsa-miR-455-3p	81.648	NM_001206864
STRADB	hsa-miR-4446-5p	81.6287	NM_018571
STRADB	hsa-miR-373-5p	80.0222	NM_001206864
STRADB	hsa-miR-371b-5p	80.0222	NM_001206864
STRADB	hsa-miR-616-5p	80.0222	NM_001206864

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Motifs and transcription factors (TFs) regulating STRADB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STRADB	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
STRADB	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
STRADB	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
STRADB	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
STRADB	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
STRADB	metacluster_3.14	WT1; WT1 (directAnnotation).
STRADB	cisbp__M07938	E2F1 (directAnnotation).
STRADB	metacluster_144.1	ZNF549 (directAnnotation).
STRADB	transfac_pro__M06688	ZKSCAN7 (directAnnotation).
STRADB	metacluster_160.6	SMARCA5 (directAnnotation). SMARCA5 (inferredBy_Orthology).
STRADB	transfac_pro__M05861	ZNF248 (directAnnotation).
STRADB	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
STRADB	taipale_tf_pairs__HOXB2_SPDEF_ANCCGGATNNNNNNMATTA_CAP_repr	HOXB2; SPDEF (directAnnotation).
STRADB	taipale_tf_pairs__PITX1_FIGLA_TAATCCNNNNCASSTG_CAP_repr	FIGLA; PITX1 (directAnnotation).
STRADB	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
STRADB	transfac_pro__M06362	ZNF730 (directAnnotation).
STRADB	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."