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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: STK39

Summary for STK39

Gene information	Gene symbol	STK39
	Ensembl ID	ENSG00000198648
	Entrez ID	27347
	Gene name	serine/threonine kinase 39
	Synonyms	DCHT\|SPAK
	Gene type	protein_coding
	UniProtAcc	Q9UEW8

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Dataset with differentially expressed gene: STK39

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.330961	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.47933	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.354349	3.00e-15

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Expression of STK39 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STK39

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STK39

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STK39	hsa-miR-1297	99.3221	NM_013233
STK39	hsa-miR-26b-5p	98.6685	NM_013233
STK39	hsa-miR-26a-5p	98.6685	NM_013233
STK39	hsa-miR-10b-3p	97.8627	NM_013233
STK39	hsa-miR-4465	97.7897	NM_013233
STK39	hsa-miR-30a-5p	96.826	NM_013233
STK39	hsa-miR-30d-5p	96.826	NM_013233
STK39	hsa-miR-30c-5p	96.826	NM_013233
STK39	hsa-miR-30e-5p	96.826	NM_013233
STK39	hsa-miR-30b-5p	96.826	NM_013233
STK39	hsa-miR-498-5p	96.6279	NM_013233
STK39	hsa-miR-4775	96.276	NM_013233
STK39	hsa-miR-1277-5p	95.821	NM_013233
STK39	hsa-miR-5582-3p	95.3432	NM_013233
STK39	hsa-miR-6501-5p	95.2756	NM_013233
STK39	hsa-miR-192-3p	94.912	NM_013233
STK39	hsa-miR-5585-5p	94.0573	NM_013233
STK39	hsa-miR-583	93.6465	NM_013233
STK39	hsa-miR-4329	93.6329	NM_013233
STK39	hsa-miR-5700	93.4979	NM_013233
STK39	hsa-miR-449c-5p	92.3767	NM_013233
STK39	hsa-miR-34b-5p	92.3767	NM_013233
STK39	hsa-miR-2682-5p	92.3767	NM_013233
STK39	hsa-miR-3145-5p	92.0583	NM_013233
STK39	hsa-miR-744-3p	91.8858	NM_013233
STK39	hsa-miR-590-3p	91.7721	NM_013233
STK39	hsa-miR-4507	91.5839	NM_013233
STK39	hsa-miR-3940-5p	91.5839	NM_013233
STK39	hsa-miR-4428	91.5324	NM_013233
STK39	hsa-miR-5011-5p	91.2369	NM_013233
STK39	hsa-miR-4269	90.3159	NM_013233
STK39	hsa-miR-6715b-5p	90.3159	NM_013233
STK39	hsa-miR-6761-5p	89.9237	NM_013233
STK39	hsa-miR-4639-5p	89.6379	NM_013233
STK39	hsa-miR-4470	89.3623	NM_013233
STK39	hsa-miR-607	89.2164	NM_013233
STK39	hsa-miR-3125	89.1701	NM_013233
STK39	hsa-miR-10527-5p	89.1259	NM_013233
STK39	hsa-miR-4251	89.0658	NM_013233
STK39	hsa-miR-675-3p	88.8821	NM_013233
STK39	hsa-miR-6507-5p	88.4225	NM_013233
STK39	hsa-miR-1827	87.662	NM_013233
STK39	hsa-miR-4658	87.5778	NM_013233
STK39	hsa-miR-6790-5p	87.5778	NM_013233
STK39	hsa-miR-1276	87.431	NM_013233
STK39	hsa-miR-3916	86.9734	NM_013233
STK39	hsa-miR-6859-5p	86.9734	NM_013233
STK39	hsa-miR-4799-5p	86.688	NM_013233
STK39	hsa-miR-3529-3p	86.4449	NM_013233
STK39	hsa-miR-4328	86.3099	NM_013233

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Motifs and transcription factors (TFs) regulating STK39

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STK39	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
STK39	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
STK39	metacluster_35.7	HINFP (inferredBy_Orthology).
STK39	metacluster_135.11	NR2C2 (directAnnotation).
STK39	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
STK39	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
STK39	metacluster_7.13	ZFX (directAnnotation).
STK39	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
STK39	cisbp__M00968	MTF2 (directAnnotation).
STK39	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
STK39	metacluster_160.20	JUND; PRDM15 (directAnnotation).
STK39	cisbp__M00341	PAX6 (directAnnotation).
STK39	metacluster_198.3	ZFP64 (directAnnotation).
STK39	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
STK39	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
STK39	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
STK39	cisbp__M00788	ZFY (inferredBy_Orthology).
STK39	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
STK39	metacluster_175.1	ZNF283 (directAnnotation).
STK39	hdpi__ZNF304	ZNF304 (directAnnotation).
STK39	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
STK39	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
STK39	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
STK39	transfac_pro__M01199	TRIM28 (directAnnotation).
STK39	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
STK39	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
STK39	transfac_pro__M03806	ZBTB7C (directAnnotation).
STK39	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
STK39	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
STK39	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
STK39	transfac_pro__M02089	E2F3 (directAnnotation).
STK39	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
STK39	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
STK39	transfac_pro__M04817	ZBTB33 (directAnnotation).
STK39	tfdimers__MD00483	ZBTB14 (directAnnotation).
STK39	cisbp__M07938	E2F1 (directAnnotation).
STK39	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
STK39	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
STK39	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
STK39	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
STK39	jaspar__MA1122.1	TFDP1 (directAnnotation).
STK39	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
STK39	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."