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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: STK38

Summary for STK38

Gene information	Gene symbol	STK38
	Ensembl ID	ENSG00000112079
	Entrez ID	11329
	Gene name	serine/threonine kinase 38
	Synonyms	NDR\|NDR1
	Gene type	protein_coding
	UniProtAcc	Q15208

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Dataset with differentially expressed gene: STK38

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.419306	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.459445	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.27444	4.55e-36
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.254258	1.23e-06
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.281809	0.00e+00

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Expression of STK38 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STK38

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STK38

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STK38	hsa-miR-651-3p	98.6763	NM_001305102
STK38	hsa-miR-624-5p	94.5804	NM_001305102
STK38	hsa-miR-12123	94.0544	NM_001305102
STK38	hsa-miR-124-3p	93.686	NM_001305102
STK38	hsa-miR-506-3p	93.686	NM_001305102
STK38	hsa-miR-654-5p	93.4137	NM_001305102
STK38	hsa-miR-137-3p	92.8139	NM_001305102
STK38	hsa-miR-541-3p	92.3311	NM_001305102
STK38	hsa-miR-5700	91.5173	NM_001305102
STK38	hsa-miR-20a-5p	90.5647	NM_001305102
STK38	hsa-miR-106b-5p	90.5647	NM_001305102
STK38	hsa-miR-4672	90.1134	NM_001305102
STK38	hsa-miR-4668-3p	89.2863	NM_001305102
STK38	hsa-miR-892c-5p	89.1201	NM_001305102
STK38	hsa-miR-17-5p	88.436	NM_001305102
STK38	hsa-miR-106a-5p	88.436	NM_001305102
STK38	hsa-miR-93-5p	88.436	NM_001305102
STK38	hsa-miR-20b-5p	88.436	NM_001305102
STK38	hsa-miR-526b-3p	88.436	NM_001305102
STK38	hsa-miR-519d-3p	88.436	NM_001305102
STK38	hsa-miR-6165	87.805	NM_001305102
STK38	hsa-miR-494-5p	87.7717	NM_001305102
STK38	hsa-miR-323b-5p	87.7717	NM_001305102
STK38	hsa-miR-410-5p	87.7717	NM_001305102
STK38	hsa-miR-1323	86.3543	NM_001305102
STK38	hsa-miR-3064-5p	84.6407	NM_001305102
STK38	hsa-miR-3085-3p	84.6407	NM_001305102
STK38	hsa-miR-6504-5p	84.6407	NM_001305102
STK38	hsa-miR-889-5p	84.3261	NM_001305102
STK38	hsa-miR-4753-3p	83.7223	NM_001305102
STK38	hsa-miR-548o-3p	83.443	NM_001305102
STK38	hsa-miR-586	82.8313	NM_001305102
STK38	hsa-miR-767-5p	82.7392	NM_001305102
STK38	hsa-miR-6840-3p	82.0688	NM_001305102
STK38	hsa-miR-548at-5p	81.5558	NM_001305102
STK38	hsa-miR-4687-3p	81.2641	NM_001305102
STK38	hsa-miR-4768-3p	80.3133	NM_001305102

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Motifs and transcription factors (TFs) regulating STK38

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STK38	swissregulon__hs__ELF2	ELF2 (directAnnotation).
STK38	hdpi__TP73	TP73 (directAnnotation).
STK38	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
STK38	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
STK38	transfac_pro__M04950	EGR1 (directAnnotation).
STK38	transfac_pro__M00652	NRF1 (directAnnotation).
STK38	taipale_tf_pairs__TEAD4_HOXA13_RCATWCCNNNNNNTTTAYNNN_CAP_repr	HOXA13; TEAD4 (directAnnotation).
STK38	swissregulon__hs__SPI1	SPI1 (directAnnotation).
STK38	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
STK38	hdpi__NRL	NRL (directAnnotation).
STK38	transfac_pro__M07310	SP5 (directAnnotation).
STK38	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
STK38	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
STK38	transfac_pro__M02089	E2F3 (directAnnotation).
STK38	transfac_pro__M07317	CTBP1 (directAnnotation).
STK38	transfac_pro__M12697	ZNF142 (directAnnotation).
STK38	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
STK38	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
STK38	transfac_pro__M04893	TAF1 (directAnnotation).
STK38	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
STK38	transfac_pro__M04916	TAF1 (directAnnotation).
STK38	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
STK38	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
STK38	hdpi__RARA	RARA (directAnnotation).
STK38	hdpi__HTATIP2	HTATIP2 (directAnnotation).
STK38	hdpi__HIP2	UBE2K (directAnnotation).
STK38	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
STK38	hdpi__ZNF304	ZNF304 (directAnnotation).
STK38	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
STK38	cisbp__M08228	PAX5 (directAnnotation).
STK38	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
STK38	transfac_pro__M00938	E2F1 (directAnnotation).
STK38	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
STK38	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
STK38	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
STK38	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
STK38	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
STK38	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
STK38	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
STK38	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
STK38	transfac_pro__M02090	E2F4 (directAnnotation).
STK38	transfac_pro__M03846	SMAD5 (directAnnotation).
STK38	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
STK38	metacluster_175.1	ZNF283 (directAnnotation).
STK38	hdpi__FEZF2	FEZF2 (directAnnotation).
STK38	cisbp__M00343	PAX6 (directAnnotation).
STK38	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
STK38	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
STK38	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
STK38	transfac_pro__M01199	TRIM28 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
STK38	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."