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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: STK32A

Summary for STK32A

Gene information	Gene symbol	STK32A
	Ensembl ID	ENSG00000169302
	Entrez ID	202374
	Gene name	serine/threonine kinase 32A
	Synonyms	MGC22688\|YANK1
	Gene type	protein_coding
	UniProtAcc	Q8WU08

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Dataset with differentially expressed gene: STK32A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.394331	0.00e+00

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Expression of STK32A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STK32A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STK32A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STK32A	hsa-miR-6771-3p	95.1894	NM_001287740
STK32A	hsa-miR-4433b-5p	92.9764	NM_001112724
STK32A	hsa-miR-216a-3p	92.7006	NM_001287740
STK32A	hsa-miR-128-3p	92.7006	NM_001287740
STK32A	hsa-miR-889-3p	92.592	NM_001287740
STK32A	hsa-miR-4786-5p	92.3201	NM_001287740
STK32A	hsa-miR-3681-3p	90.4198	NM_001287740
STK32A	hsa-miR-4662a-5p	89.1788	NM_001287740
STK32A	hsa-miR-5094	88.9588	NM_001287740
STK32A	hsa-miR-4800-3p	88.4187	NM_145001
STK32A	hsa-miR-1468-3p	86.2073	NM_145001
STK32A	hsa-miR-6882-3p	85.7641	NM_001112724
STK32A	hsa-miR-380-3p	85.1398	NM_001112724
STK32A	hsa-miR-656-3p	84.9948	NM_001287740
STK32A	hsa-miR-5582-5p	84.7754	NM_001287740
STK32A	hsa-miR-6778-3p	84.3169	NM_001287740
STK32A	hsa-miR-3182	83.3002	NM_001287740
STK32A	hsa-miR-6728-3p	82.1452	NM_001287740

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Motifs and transcription factors (TFs) regulating STK32A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STK32A	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
STK32A	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
STK32A	transfac_pro__M06156	ZNF75D (directAnnotation).
STK32A	cisbp__M08198	ELF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
STK32A	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."