Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE140440 | DU145 and PCÂ cell lines | Cell line | Prostate cancer | Prostate cancer | Chemotherapy | docetaxel | NA | Malignant cells | 1.0979 | 8.58e-06 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | CD8+ T cells | 0.292461 | 8.56e-43 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD4+ T cells | -0.487441 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD8+ T cells | -0.379254 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | -0.39295 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | NK cells | -0.743742 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD4+ T cells | -0.679773 | 0.00e+00 |
GSE111014 | patients | Peripheral blood mononuclear cells | Chronic lymphocytic leukemia | Chronic lymphocytic leukemia (CLL) | Targeted therapy | ibrutinib | post | NK cells | 0.266201 | 3.93e-12 |
GSE111014 | patients | Peripheral blood mononuclear cells | Chronic lymphocytic leukemia | Chronic lymphocytic leukemia (CLL) | Targeted therapy | ibrutinib | post | CD8+ T cells | -0.332492 | 8.49e-15 |
GSE131984_JQ1 | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 | NA | Malignant cells | -0.350021 | 5.74e-19 |
GSE131984_JQ1Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + paclitaxel | NA | Malignant cells | -0.486701 | 8.37e-23 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | -0.360769 | 1.31e-16 |
GSE131984_Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | palbociclib | NA | Malignant cells | -0.441764 | 1.45e-19 |
GSE108397 | 451Lu cell line | Cell line | Melanoma | Melanoma | Targeted therapy | PLX-4720 | NA | Malignant cells | -1.09952 | 0.00e+00 |
GSE164897_VemCob | A375 cell line | Cell line | Melanoma | BRAFV600E-mutant melanoma | Targeted therapy | vemurafenib + combimetinib | NA | Malignant cells | -0.401186 | 0.00e+00 |
GSE164897_VemTra | A375 cell line | Cell line | Melanoma | B+E2:E57RAFV600E-mutant melanoma | Targeted therapy | vemurafenib + trametinib | NA | Malignant cells | -0.338904 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
STK17A | metacluster_7.13 | ZFX (directAnnotation). |
STK17A | taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth | ZNF385D (directAnnotation). |
STK17A | metacluster_151.2 | ZNF23 (directAnnotation). |
STK17A | metacluster_170.2 | KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology). |
STK17A | kznf__ZNF783_Imbeault2017_OM_MEME | ZNF783 (directAnnotation). |
STK17A | metacluster_144.3 | ZNF704; ZNF704 (directAnnotation). |
STK17A | homer__TWVGGTCCGC_HINFP | HINFP (directAnnotation). |
STK17A | metacluster_135.10 | MBD2; MBD2; MECP2; MECP2 (directAnnotation). |
STK17A | jaspar__MA0079.5 | SP1 (directAnnotation). |
STK17A | kznf__ZNF594_Schmitges2016_RCADE | ZNF594 (directAnnotation). |
STK17A | metacluster_195.2 | EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology). |
STK17A | kznf__ZBTB14_Schmitges2016_RCADE | ZBTB14 (directAnnotation). |
STK17A | transfac_pro__M04617 | ZBTB7A (directAnnotation). |
STK17A | metacluster_3.5 | KLF14; KLF15; KLF15; KLF16 (directAnnotation). |
STK17A | taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth | E2F2 (directAnnotation). |
STK17A | transfac_pro__M07387 | ZBTB7A (directAnnotation). |
STK17A | transfac_pro__M07436 | WT1 (directAnnotation). |
STK17A | transfac_pro__M00716 | ZBTB14 (directAnnotation). |
STK17A | swissregulon__hs__CHD1 | CHD1 (directAnnotation). |
STK17A | hdpi__HIP2 | UBE2K (directAnnotation). |
STK17A | taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr | GCM1; SPDEF (directAnnotation). |
STK17A | transfac_pro__M04893 | TAF1 (directAnnotation). |
STK17A | transfac_pro__M03876 | ZBTB33 (directAnnotation). |
STK17A | metacluster_15.2 | E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology). |
STK17A | metacluster_133.1 | ZNF304; ZNF304; ZSCAN22 (directAnnotation). |
STK17A | kznf__ZNF441_Imbeault2017_RP_RCADE | ZNF441 (directAnnotation). |
STK17A | transfac_pro__M02913 | SP140 (inferredBy_Orthology). |
STK17A | jaspar__MA0185.1 | DEAF1 (inferredBy_Orthology). |
STK17A | jaspar__MA0748.2 | YY2 (directAnnotation). |
STK17A | transfac_pro__M01090 | SMAD9 (inferredBy_Orthology). |
STK17A | transfac_pro__M01088 | DEAF1 (inferredBy_Orthology). |
STK17A | flyfactorsurvey__Mad_FlyReg_FBgn0011648 | SMAD9 (inferredBy_Orthology). |
STK17A | transfac_pro__M00430 | E2F1 (directAnnotation). |
STK17A | metacluster_126.3 | LIN28B; LIN28B (directAnnotation). |
STK17A | homer__NANTGCSGCA_Zfp57 | ZFP57 (directAnnotation). |
STK17A | transfac_pro__M01199 | TRIM28 (directAnnotation). |
STK17A | metacluster_151.1 | KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation). |
STK17A | transfac_pro__M02865 | GMEB1 (inferredBy_Orthology). |
STK17A | transfac_pro__M08894 | OVOL1; OVOL2 (directAnnotation). |
STK17A | kznf__ZFP57_Imbeault2017_RP_ChIP-seq | ZFP57 (directAnnotation). |
STK17A | hdpi__TIMELESS | TIMELESS (directAnnotation). |
STK17A | metacluster_55.3 | E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology). |
STK17A | idmmpmm__Mad | SMAD9 (inferredBy_Orthology). |
STK17A | metacluster_191.5 | SPDEF (inferredBy_Orthology). |
STK17A | taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr | E2F1; ELK1 (directAnnotation). |
STK17A | transfac_pro__M00938 | E2F1 (directAnnotation). |
STK17A | transfac_pro__M01238 | DEAF1 (inferredBy_Orthology). |
STK17A | taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr | ZBTB37 (directAnnotation). |
STK17A | dbtfbs__ZNF407_representative_N1 | ZNF407 (directAnnotation). |
STK17A | hdpi__RARA | RARA (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |