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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STEAP3

Summary for STEAP3

Gene information	Gene symbol	STEAP3
	Ensembl ID	ENSG00000115107
	Entrez ID	55240
	Gene name	STEAP3 metalloreductase
	Synonyms	dudlin-2\|STMP3\|TSAP6
	Gene type	protein_coding
	UniProtAcc	Q658P3

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Dataset with differentially expressed gene: STEAP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.778486	1.81e-02

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Expression of STEAP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STEAP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STEAP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STEAP3	hsa-miR-605-3p	98.0015	NM_138637
STEAP3	hsa-miR-9-5p	96.9672	NM_138637
STEAP3	hsa-miR-6728-3p	94.2845	NM_138637
STEAP3	hsa-miR-6126	92.3591	NM_001008410
STEAP3	hsa-miR-6132	91.8921	NM_138637
STEAP3	hsa-miR-6836-5p	91.7111	NM_138637
STEAP3	hsa-miR-760	90.6474	NM_001008410
STEAP3	hsa-miR-4491	90.5481	NM_001008410
STEAP3	hsa-miR-4657	90.5481	NM_001008410
STEAP3	hsa-miR-4639-3p	89.8614	NM_138637
STEAP3	hsa-miR-9500	89.4496	NM_001008410
STEAP3	hsa-miR-6756-5p	88.2167	NM_001008410
STEAP3	hsa-miR-6721-5p	86.5728	NM_138637
STEAP3	hsa-miR-5689	86.4868	NM_001008410
STEAP3	hsa-miR-4789-5p	86.1614	NM_001008410
STEAP3	hsa-miR-1827	85.2036	NM_138637
STEAP3	hsa-miR-5582-5p	84.4634	NM_138637
STEAP3	hsa-miR-4271	83.7202	NM_001008410
STEAP3	hsa-miR-1249-5p	83.2384	NM_001008410
STEAP3	hsa-miR-6797-5p	83.2384	NM_001008410
STEAP3	hsa-miR-6766-5p	81.0445	NM_001008410
STEAP3	hsa-miR-6780b-5p	80.9942	NM_001008410
STEAP3	hsa-miR-4725-3p	80.9942	NM_001008410
STEAP3	hsa-miR-124-3p	80.7858	NM_138637
STEAP3	hsa-miR-506-3p	80.7858	NM_138637
STEAP3	hsa-miR-4789-3p	80.0909	NM_001008410

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Motifs and transcription factors (TFs) regulating STEAP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."