Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STEAP2

Summary for STEAP2

Gene information	Gene symbol	STEAP2
	Ensembl ID	ENSG00000157214
	Entrez ID	261729
	Gene name	STEAP2 metalloreductase
	Synonyms	IPCA-1\|PCANAP1\|STAMP1\|STMP
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: STEAP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.2022	5.90e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.588636	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.22759	0.00e+00

Top

Expression of STEAP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to STEAP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating STEAP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STEAP2	hsa-miR-126-5p	99.4702	NM_001040665
STEAP2	hsa-miR-4775	99.1436	NM_001040665
STEAP2	hsa-miR-1277-5p	98.6984	NM_001040665
STEAP2	hsa-miR-5197-5p	98.541	NM_001040665
STEAP2	hsa-miR-3680-3p	97.441	NM_001040665
STEAP2	hsa-miR-944	97.1842	NM_001040665
STEAP2	hsa-miR-10399-5p	97.1136	NM_001040665
STEAP2	hsa-miR-6504-3p	97.1136	NM_001040665
STEAP2	hsa-miR-656-3p	97.0332	NM_001040665
STEAP2	hsa-miR-4795-3p	96.1022	NM_001040665
STEAP2	hsa-miR-4712-3p	95.948	NM_001040665
STEAP2	hsa-miR-590-3p	95.6136	NM_001040665
STEAP2	hsa-miR-582-5p	95.4692	NM_001040665
STEAP2	hsa-miR-548e-5p	94.6804	NM_001040665
STEAP2	hsa-miR-501-5p	93.7374	NM_001040665
STEAP2	hsa-miR-548as-5p	93.4931	NM_001040665
STEAP2	hsa-miR-186-5p	93.1693	NM_001040665
STEAP2	hsa-miR-9983-3p	92.8563	NM_001040665
STEAP2	hsa-miR-16-1-3p	92.7395	NM_001040665
STEAP2	hsa-miR-129-5p	92.2857	NM_001040665
STEAP2	hsa-miR-559	91.5376	NM_001040665
STEAP2	hsa-miR-4517	91.3669	NM_001040665
STEAP2	hsa-miR-607	91.345	NM_001040665
STEAP2	hsa-miR-374a-5p	91.3242	NM_001040665
STEAP2	hsa-miR-372-5p	91.2799	NM_001040665
STEAP2	hsa-miR-4672	91.0432	NM_001244946
STEAP2	hsa-miR-335-3p	90.8306	NM_001040665
STEAP2	hsa-miR-539-5p	90.5427	NM_001040665
STEAP2	hsa-miR-4668-3p	90.4948	NM_001040665
STEAP2	hsa-miR-5692a	90.4879	NM_001040665
STEAP2	hsa-miR-6888-5p	90.4319	NM_001040665
STEAP2	hsa-miR-3714	89.8363	NM_001244946
STEAP2	hsa-miR-548k	89.4964	NM_001040665
STEAP2	hsa-miR-548av-5p	89.4964	NM_001040665
STEAP2	hsa-miR-8054	89.2713	NM_001040665
STEAP2	hsa-miR-548y	89.0884	NM_001040665
STEAP2	hsa-miR-548aq-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548h-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548w	89.0884	NM_001040665
STEAP2	hsa-miR-548ar-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548c-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548ab	89.0884	NM_001040665
STEAP2	hsa-miR-548j-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548am-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548o-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548d-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548au-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548ap-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548ae-5p	89.0884	NM_001040665
STEAP2	hsa-miR-548ay-5p	89.0884	NM_001040665

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating STEAP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STEAP2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
STEAP2	metacluster_52.11	ZNF184 (directAnnotation).
STEAP2	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
STEAP2	metacluster_35.7	HINFP (inferredBy_Orthology).
STEAP2	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
STEAP2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
STEAP2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
STEAP2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
STEAP2	transfac_pro__M04617	ZBTB7A (directAnnotation).
STEAP2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
STEAP2	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
STEAP2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
STEAP2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
STEAP2	transfac_pro__M07387	ZBTB7A (directAnnotation).
STEAP2	transfac_pro__M07436	WT1 (directAnnotation).
STEAP2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
STEAP2	transfac_pro__M00716	ZBTB14 (directAnnotation).
STEAP2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
STEAP2	hdpi__HIP2	UBE2K (directAnnotation).
STEAP2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
STEAP2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
STEAP2	transfac_pro__M04893	TAF1 (directAnnotation).
STEAP2	transfac_pro__M03876	ZBTB33 (directAnnotation).
STEAP2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
STEAP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
STEAP2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
STEAP2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
STEAP2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
STEAP2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
STEAP2	transfac_pro__M02089	E2F3 (directAnnotation).
STEAP2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
STEAP2	transfac_pro__M04817	ZBTB33 (directAnnotation).
STEAP2	metacluster_143.13	ZBTB7A (directAnnotation).
STEAP2	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
STEAP2	tfdimers__MD00483	ZBTB14 (directAnnotation).
STEAP2	cisbp__M07938	E2F1 (directAnnotation).
STEAP2	cisbp__M00968	MTF2 (directAnnotation).
STEAP2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
STEAP2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
STEAP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
STEAP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
STEAP2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."