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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STC2

Summary for STC2

Gene information	Gene symbol	STC2
	Ensembl ID	ENSG00000113739
	Entrez ID	8614
	Gene name	stanniocalcin 2
	Synonyms	STC-2
	Gene type	protein_coding
	UniProtAcc	O76061

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Dataset with differentially expressed gene: STC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.76868	1.49e-11
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.85159	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.296895	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-1.23363	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.588763	0.00e+00

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Expression of STC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STC2	hsa-miR-3912-5p	97.3217	NM_003714
STC2	hsa-miR-24-3p	94.8163	NM_003714
STC2	hsa-miR-766-5p	94.6321	NM_003714
STC2	hsa-miR-1243	94.3322	NM_003714
STC2	hsa-miR-1-3p	91.6526	NM_003714
STC2	hsa-miR-206	91.6526	NM_003714
STC2	hsa-miR-4756-3p	91.6263	NM_003714
STC2	hsa-miR-613	91.1169	NM_003714
STC2	hsa-miR-545-5p	90.8902	NM_003714
STC2	hsa-miR-4487	86.9054	NM_003714
STC2	hsa-miR-4284	86.4126	NM_003714
STC2	hsa-miR-4423-5p	85.5616	NM_003714
STC2	hsa-miR-3668	85.5503	NM_003714
STC2	hsa-miR-4694-3p	84.6232	NM_003714
STC2	hsa-miR-4760-5p	84.0457	NM_003714
STC2	hsa-miR-4699-3p	83.8341	NM_003714
STC2	hsa-miR-6762-3p	83.5522	NM_003714
STC2	hsa-miR-3667-3p	83.3504	NM_003714
STC2	hsa-miR-5582-3p	83.2151	NM_003714
STC2	hsa-miR-8061	82.0242	NM_003714
STC2	hsa-miR-2115-5p	81.7533	NM_003714
STC2	hsa-miR-629-3p	81.5181	NM_003714
STC2	hsa-miR-208b-5p	81.0893	NM_003714
STC2	hsa-miR-208a-5p	81.0893	NM_003714
STC2	hsa-miR-7157-5p	80.093	NM_003714

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Motifs and transcription factors (TFs) regulating STC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STC2	metacluster_172.23	ZBTB32; ZBTB32 (directAnnotation).
STC2	metacluster_14.28	CLOCK (inferredBy_Orthology).
STC2	transfac_pro__M05298	OVOL3 (directAnnotation).
STC2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
STC2	cisbp__M00341	PAX6 (directAnnotation).
STC2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
STC2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
STC2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."