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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: STAT2

Summary for STAT2

Gene information	Gene symbol	STAT2
	Ensembl ID	ENSG00000170581
	Entrez ID	6773
	Gene name	signal transducer and activator of transcription 2
	Synonyms	STAT113
	Gene type	protein_coding
	UniProtAcc	P52630

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Dataset with differentially expressed gene: STAT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Mono/Macro	-0.280713	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.289161	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.501782	8.56e-05

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Expression of STAT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STAT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STAT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STAT2	hsa-miR-4433a-3p	95.4819	NM_005419
STAT2	hsa-let-7c-3p	89.4374	NM_005419
STAT2	hsa-miR-665	88.4807	NM_005419
STAT2	hsa-miR-6825-5p	85.453	NM_005419
STAT2	hsa-miR-24-3p	84.7943	NM_005419
STAT2	hsa-miR-6791-5p	84.067	NM_005419
STAT2	hsa-miR-4531	83.5522	NM_005419
STAT2	hsa-miR-616-5p	83.2578	NM_005419
STAT2	hsa-miR-371b-5p	83.2578	NM_005419
STAT2	hsa-miR-373-5p	83.2578	NM_005419
STAT2	hsa-miR-4292	82.5676	NM_005419
STAT2	hsa-miR-7111-5p	81.7895	NM_005419
STAT2	hsa-miR-3202	80.8215	NM_005419

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Motifs and transcription factors (TFs) regulating STAT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STAT2	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
STAT2	metacluster_9.47	PAX7 (inferredBy_Orthology).
STAT2	jaspar__MA1509.1	IRF6 (directAnnotation).
STAT2	transfac_pro__M04887	TCF12 (directAnnotation).
STAT2	kznf__ZNF33B_Imbeault2017_RP_RCADE	ZNF33B (directAnnotation).
STAT2	tfdimers__MD00488	ELF1; HDX (directAnnotation).
STAT2	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
STAT2	transfac_pro__M12556	ETV4 (directAnnotation).
STAT2	taipale_tf_pairs__FLI1_MAX_RSCGGAANCACGTGN_CAP	FLI1; MAX (directAnnotation).
STAT2	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
STAT2	metacluster_2.6	down	Mono/Macro	GSE197268_Axi-cel	post
STAT2	metacluster_2.7	down	Mono/Macro	GSE197268_Axi-cel	post
STAT2	metacluster_2.6	down	B cells	GSE207422_Tor	post
STAT2	metacluster_2.7	down	B cells	GSE207422_Tor	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."