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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STAP1

Summary for STAP1

Gene information	Gene symbol	STAP1
	Ensembl ID	ENSG00000035720
	Entrez ID	26228
	Gene name	signal transducing adaptor family member 1
	Synonyms	BRDG1\|STAP-1
	Gene type	protein_coding
	UniProtAcc	Q9ULZ2

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Dataset with differentially expressed gene: STAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.669871	6.83e-09

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Expression of STAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STAP1	hsa-miR-4753-3p	97.2489	NM_012108
STAP1	hsa-miR-6809-3p	93.3626	NM_012108
STAP1	hsa-miR-5579-5p	91.126	NM_012108
STAP1	hsa-miR-4768-3p	90.8085	NM_012108
STAP1	hsa-miR-1305	90.0893	NM_012108
STAP1	hsa-miR-6783-5p	88.8986	NM_012108
STAP1	hsa-miR-150-3p	86.7137	NM_012108
STAP1	hsa-miR-130b-5p	86.1803	NM_012108
STAP1	hsa-miR-130a-5p	86.1803	NM_012108
STAP1	hsa-miR-125a-3p	86.0444	NM_012108
STAP1	hsa-miR-450a-1-3p	84.9463	NM_012108
STAP1	hsa-miR-146b-3p	84.8203	NM_012108
STAP1	hsa-miR-12120	82.627	NM_012108
STAP1	hsa-miR-5571-5p	82.6032	NM_012108
STAP1	hsa-miR-3688-5p	80.9541	NM_012108

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Motifs and transcription factors (TFs) regulating STAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STAP1	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."