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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STAM

Summary for STAM

Gene information	Gene symbol	STAM
	Ensembl ID	ENSG00000136738
	Entrez ID	8027
	Gene name	signal transducing adaptor molecule
	Synonyms	STAM1
	Gene type	protein_coding
	UniProtAcc	Q92783

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Dataset with differentially expressed gene: STAM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.621779	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.254496	0.00e+00

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Expression of STAM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STAM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STAM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STAM	hsa-miR-4697-3p	99.8802	NM_001324282
STAM	hsa-miR-5011-5p	98.8941	NM_001324282
STAM	hsa-miR-8066	95.6649	NM_001324282
STAM	hsa-miR-302c-5p	95.3327	NM_001324282
STAM	hsa-miR-4495	95.1015	NM_001324282
STAM	hsa-miR-579-3p	94.7714	NM_001324282
STAM	hsa-miR-664b-3p	94.7714	NM_001324282
STAM	hsa-miR-5693	94.1214	NM_001324282
STAM	hsa-miR-488-3p	93.4993	NM_001324282
STAM	hsa-miR-664a-3p	93.1533	NM_001324282
STAM	hsa-miR-888-5p	92.489	NM_001324282
STAM	hsa-miR-3662	92.3352	NM_001324282
STAM	hsa-miR-142-3p	92.2847	NM_001324282
STAM	hsa-miR-5681a	91.6141	NM_001324282
STAM	hsa-miR-6730-5p	91.6141	NM_001324282
STAM	hsa-miR-3617-5p	91.5148	NM_001324282
STAM	hsa-miR-641	91.5148	NM_001324282
STAM	hsa-miR-1252-3p	91.457	NM_001324282
STAM	hsa-miR-6124	90.4138	NM_001324282
STAM	hsa-miR-145-5p	90.3967	NM_001324282
STAM	hsa-miR-5195-3p	90.3967	NM_001324282
STAM	hsa-miR-3661	90.369	NM_001324282
STAM	hsa-miR-3143	89.7811	NM_001324282
STAM	hsa-miR-526b-5p	88.2463	NM_001324282
STAM	hsa-miR-4729	87.9629	NM_001324282
STAM	hsa-miR-144-5p	87.3364	NM_001324282
STAM	hsa-miR-570-5p	87.1595	NM_001324282
STAM	hsa-miR-548ag	87.1595	NM_001324282
STAM	hsa-miR-548ba	87.1595	NM_001324282
STAM	hsa-miR-548ai	87.1595	NM_001324282
STAM	hsa-miR-4635	86.8651	NM_001324282
STAM	hsa-miR-4724-3p	86.1762	NM_001324282
STAM	hsa-miR-190a-3p	86.1224	NM_001324282
STAM	hsa-miR-5696	85.9431	NM_001324282
STAM	hsa-miR-493-5p	85.6075	NM_001324282
STAM	hsa-miR-631	84.989	NM_001324282
STAM	hsa-miR-1248	84.9778	NM_001324282
STAM	hsa-miR-616-5p	84.2259	NM_001324282
STAM	hsa-miR-373-5p	84.2259	NM_001324282
STAM	hsa-miR-371b-5p	84.2259	NM_001324282
STAM	hsa-miR-4698	84.1081	NM_001324282
STAM	hsa-miR-510-3p	83.0762	NM_001324282
STAM	hsa-miR-3658	82.7018	NM_001324282
STAM	hsa-miR-892b	82.1634	NM_001324282
STAM	hsa-miR-4733-5p	81.7956	NM_001324282
STAM	hsa-miR-12130	81.6886	NM_001324282
STAM	hsa-miR-1273h-3p	81.4703	NM_001324282
STAM	hsa-miR-548m	81.4086	NM_001324282
STAM	hsa-miR-5003-5p	81.3193	NM_001324282
STAM	hsa-miR-12136	80.9386	NM_001324282

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Motifs and transcription factors (TFs) regulating STAM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STAM	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
STAM	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."