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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STAG2

Summary for STAG2

Gene information	Gene symbol	STAG2
	Ensembl ID	ENSG00000101972
	Entrez ID	10735
	Gene name	stromal antigen 2
	Synonyms	SA-2\|SA2\|SCC3B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: STAG2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.299857	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.357856	8.32e-19
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.424092	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.265608	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.347215	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.269144	4.03e-13
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.290588	1.06e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.263577	2.10e-08

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Expression of STAG2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STAG2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STAG2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STAG2	hsa-miR-5011-5p	99.9738	NM_001042749
STAG2	hsa-miR-3163	99.6531	NM_001042749
STAG2	hsa-miR-548c-3p	99.5287	NM_001042749
STAG2	hsa-miR-190a-3p	99.5013	NM_001282418
STAG2	hsa-miR-338-5p	98.6883	NM_001282418
STAG2	hsa-miR-590-3p	98.2256	NM_001282418
STAG2	hsa-miR-877-3p	97.9031	NM_001042749
STAG2	hsa-miR-4735-5p	97.4967	NM_001042749
STAG2	hsa-miR-4698	97.4296	NM_001042749
STAG2	hsa-miR-570-3p	97.3944	NM_001042749
STAG2	hsa-miR-4762-3p	97.2806	NM_001042749
STAG2	hsa-miR-140-3p	94.6108	NM_001282418
STAG2	hsa-miR-4775	94.4333	NM_001282418
STAG2	hsa-miR-197-3p	94.3791	NM_001282418
STAG2	hsa-miR-548n	94.3542	NM_001282418
STAG2	hsa-miR-5580-3p	93.9458	NM_001282418
STAG2	hsa-miR-8080	93.8249	NM_001042749
STAG2	hsa-miR-1290	92.8384	NM_001282418
STAG2	hsa-miR-4279	92.6372	NM_001042749
STAG2	hsa-miR-3662	92.5998	NM_001282418
STAG2	hsa-miR-5706	92.3177	NM_001282418
STAG2	hsa-miR-4782-5p	92.3177	NM_001282418
STAG2	hsa-miR-206	92.2692	NM_001042749
STAG2	hsa-miR-1-3p	92.2692	NM_001042749
STAG2	hsa-miR-518a-5p	92.1328	NM_001042749
STAG2	hsa-miR-527	92.1328	NM_001042749
STAG2	hsa-miR-5692a	92.0811	NM_001282418
STAG2	hsa-miR-4503	92.0177	NM_001282418
STAG2	hsa-miR-5579-3p	91.8654	NM_001042749
STAG2	hsa-miR-580-5p	91.5353	NM_001042749
STAG2	hsa-miR-613	91.2049	NM_001042749
STAG2	hsa-miR-5003-5p	91.1326	NM_001042749
STAG2	hsa-miR-488-3p	90.5493	NM_001042749
STAG2	hsa-miR-6828-3p	90.5082	NM_001042749
STAG2	hsa-miR-1183	90.4327	NM_001042749
STAG2	hsa-miR-3622b-5p	90.3878	NM_001282418
STAG2	hsa-miR-4530	90.3305	NM_001042749
STAG2	hsa-miR-875-5p	90.1235	NM_001282418
STAG2	hsa-miR-12131	89.9303	NM_001282418
STAG2	hsa-miR-6839-5p	89.8762	NM_001282418
STAG2	hsa-miR-6071	89.8473	NM_001042749
STAG2	hsa-miR-3650	89.6323	NM_001042749
STAG2	hsa-miR-12128	89.5925	NM_001042749
STAG2	hsa-miR-3127-5p	89.4153	NM_001042749
STAG2	hsa-miR-153-5p	89.2072	NM_001282418
STAG2	hsa-miR-21-5p	89.0306	NM_001042749
STAG2	hsa-miR-3688-3p	88.4783	NM_001042749
STAG2	hsa-miR-4482-3p	88.4311	NM_001282418
STAG2	hsa-miR-590-5p	88.2884	NM_001042749
STAG2	hsa-miR-4263	87.8292	NM_001042749

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Motifs and transcription factors (TFs) regulating STAG2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STAG2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
STAG2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
STAG2	transfac_pro__M07397	ZNF148 (directAnnotation).
STAG2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
STAG2	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
STAG2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
STAG2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
STAG2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
STAG2	metacluster_7.13	ZFX (directAnnotation).
STAG2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
STAG2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
STAG2	transfac_pro__M01175	ZBTB7B (directAnnotation).
STAG2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
STAG2	tfdimers__MD00151	CHURC1 (directAnnotation).
STAG2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
STAG2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
STAG2	transfac_pro__M01303	SP1 (directAnnotation).
STAG2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
STAG2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
STAG2	transfac_pro__M02090	E2F4 (directAnnotation).
STAG2	transfac_pro__M01714	KLF15 (directAnnotation).
STAG2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
STAG2	jaspar__MA1122.1	TFDP1 (directAnnotation).
STAG2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
STAG2	transfac_pro__M02089	E2F3 (directAnnotation).
STAG2	transfac_pro__M12604	ZNF444 (directAnnotation).
STAG2	metacluster_3.14	WT1; WT1 (directAnnotation).
STAG2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
STAG2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
STAG2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
STAG2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
STAG2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
STAG2	cisbp__M07938	E2F1 (directAnnotation).
STAG2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
STAG2	transfac_pro__M07436	WT1 (directAnnotation).
STAG2	transfac_pro__M02281	SP1 (directAnnotation).
STAG2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
STAG2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
STAG2	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
STAG2	transfac_pro__M02898	SMAD3 (directAnnotation).
STAG2	transfac_public__M00491	PATZ1 (directAnnotation).
STAG2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
STAG2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
STAG2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
STAG2	hdpi__TP73	TP73 (directAnnotation).
STAG2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
STAG2	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
STAG2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
STAG2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
STAG2	jaspar__MA1708.1	ETV7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."