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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STAG1

Summary for STAG1

Gene information	Gene symbol	STAG1
	Ensembl ID	ENSG00000118007
	Entrez ID	10274
	Gene name	stromal antigen 1
	Synonyms	SA-1\|SA1\|SCC3A
	Gene type	protein_coding
	UniProtAcc	Q8WVM7

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Dataset with differentially expressed gene: STAG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.336434	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.382443	0.00e+00

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Expression of STAG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STAG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STAG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STAG1	hsa-miR-3163	98.9903	NM_005862
STAG1	hsa-miR-4282	98.6695	NM_005862
STAG1	hsa-miR-6862-5p	97.4802	NM_005862
STAG1	hsa-miR-4253	97.4802	NM_005862
STAG1	hsa-miR-96-5p	96.2099	NM_005862
STAG1	hsa-miR-182-5p	96.2099	NM_005862
STAG1	hsa-miR-664b-3p	96.0398	NM_005862
STAG1	hsa-miR-579-3p	96.0398	NM_005862
STAG1	hsa-miR-7150	95.4658	NM_005862
STAG1	hsa-miR-5692a	94.8863	NM_005862
STAG1	hsa-miR-6132	94.5751	NM_005862
STAG1	hsa-miR-6836-5p	94.5751	NM_005862
STAG1	hsa-miR-12133	94.4652	NM_005862
STAG1	hsa-miR-1271-5p	94.4652	NM_005862
STAG1	hsa-miR-1207-5p	94.2326	NM_005862
STAG1	hsa-miR-4763-3p	94.2097	NM_005862
STAG1	hsa-miR-335-5p	94.1194	NM_005862
STAG1	hsa-miR-133a-5p	93.7103	NM_005862
STAG1	hsa-miR-548at-5p	93.0852	NM_005862
STAG1	hsa-miR-9985	92.9803	NM_005862
STAG1	hsa-miR-27a-3p	92.9803	NM_005862
STAG1	hsa-miR-27b-3p	92.9803	NM_005862
STAG1	hsa-miR-548c-3p	92.4988	NM_005862
STAG1	hsa-miR-4719	92.416	NM_005862
STAG1	hsa-miR-3662	90.1467	NM_005862
STAG1	hsa-miR-513b-5p	89.4551	NM_005862
STAG1	hsa-miR-548an	88.3107	NM_005862
STAG1	hsa-miR-410-3p	88.0958	NM_005862
STAG1	hsa-miR-208b-5p	87.9424	NM_005862
STAG1	hsa-miR-208a-5p	87.9424	NM_005862
STAG1	hsa-miR-4760-3p	87.4068	NM_005862
STAG1	hsa-miR-3120-3p	85.8135	NM_005862
STAG1	hsa-miR-4747-5p	85.4931	NM_005862
STAG1	hsa-miR-5196-5p	85.4931	NM_005862
STAG1	hsa-let-7c-3p	85.2934	NM_005862
STAG1	hsa-miR-1197	85.1971	NM_005862
STAG1	hsa-miR-6875-3p	84.8074	NM_005862
STAG1	hsa-miR-3934-5p	84.8001	NM_005862
STAG1	hsa-miR-8485	84.5843	NM_005862
STAG1	hsa-miR-580-3p	84.5466	NM_005862
STAG1	hsa-miR-5590-3p	83.8254	NM_005862
STAG1	hsa-miR-142-5p	83.8254	NM_005862
STAG1	hsa-miR-3148	83.7129	NM_005862
STAG1	hsa-miR-5011-3p	83.7089	NM_005862
STAG1	hsa-miR-4650-3p	83.4947	NM_005862
STAG1	hsa-miR-4742-3p	83.0538	NM_005862
STAG1	hsa-miR-550b-3p	82.9823	NM_005862
STAG1	hsa-miR-4736	82.528	NM_005862
STAG1	hsa-miR-3682-5p	82.3149	NM_005862
STAG1	hsa-miR-3692-3p	82.1166	NM_005862

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Motifs and transcription factors (TFs) regulating STAG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STAG1	metacluster_7.13	ZFX (directAnnotation).
STAG1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
STAG1	metacluster_151.2	ZNF23 (directAnnotation).
STAG1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
STAG1	transfac_pro__M05479	ZNF580 (directAnnotation).
STAG1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
STAG1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
STAG1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
STAG1	metacluster_182.10	ZFX (directAnnotation).
STAG1	hdpi__ETV4	ETV4 (directAnnotation).
STAG1	jaspar__MA0748.2	YY2 (directAnnotation).
STAG1	transfac_pro__M05628	ZNF735 (directAnnotation).
STAG1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
STAG1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
STAG1	jaspar__MA0079.5	SP1 (directAnnotation).
STAG1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
STAG1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
STAG1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
STAG1	transfac_pro__M04950	EGR1 (directAnnotation).
STAG1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
STAG1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
STAG1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
STAG1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
STAG1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
STAG1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
STAG1	transfac_pro__M00652	NRF1 (directAnnotation).
STAG1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
STAG1	transfac_pro__M04866	HDAC2 (directAnnotation).
STAG1	jaspar__MA1122.1	TFDP1 (directAnnotation).
STAG1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
STAG1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
STAG1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."