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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: ST8SIA4

Summary for ST8SIA4

Gene informationGene symbol

ST8SIA4

Ensembl ID

ENSG00000113532

Entrez ID

7903

Gene nameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SynonymsPST|PST1|SIAT8D
Gene typeprotein_coding
UniProtAcc

Q92187


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Dataset with differentially expressed gene: ST8SIA4

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postNeutrophils-0.2889862.52e-07

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Expression of ST8SIA4 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ST8SIA4

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ST8SIA4

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ST8SIA4hsa-miR-607498.658NM_175052
ST8SIA4hsa-miR-426298.47NM_005668
ST8SIA4hsa-miR-4659a-3p97.5871NM_005668
ST8SIA4hsa-miR-4659b-3p97.5871NM_005668
ST8SIA4hsa-miR-181d-5p97.2964NM_005668
ST8SIA4hsa-miR-181a-5p97.2964NM_005668
ST8SIA4hsa-miR-181b-5p97.2964NM_005668
ST8SIA4hsa-miR-181c-5p97.2964NM_005668
ST8SIA4hsa-miR-391196.0021NM_175052
ST8SIA4hsa-miR-1277-5p95.264NM_005668
ST8SIA4hsa-miR-3613-3p94.8255NM_005668
ST8SIA4hsa-miR-126394.5917NM_005668
ST8SIA4hsa-miR-1213694.0716NM_005668
ST8SIA4hsa-miR-4789-5p93.9873NM_005668
ST8SIA4hsa-miR-3529-3p93.692NM_175052
ST8SIA4hsa-miR-208a-5p92.9805NM_005668
ST8SIA4hsa-miR-208b-5p92.9805NM_005668
ST8SIA4hsa-miR-480392.4484NM_175052
ST8SIA4hsa-miR-1468-3p92.1556NM_005668
ST8SIA4hsa-miR-60791.7757NM_005668
ST8SIA4hsa-miR-1207-3p90.7237NM_005668
ST8SIA4hsa-miR-5011-5p90.6437NM_005668
ST8SIA4hsa-miR-670-3p90.626NM_005668
ST8SIA4hsa-miR-4477a89.5082NM_005668
ST8SIA4hsa-miR-397389.3626NM_005668
ST8SIA4hsa-miR-548c-3p89.1552NM_005668
ST8SIA4hsa-miR-130389.0171NM_005668
ST8SIA4hsa-miR-410-3p88.6926NM_005668
ST8SIA4hsa-miR-147a88.5339NM_175052
ST8SIA4hsa-miR-480188.4897NM_005668
ST8SIA4hsa-miR-4789-3p88.2641NM_005668
ST8SIA4hsa-miR-143-3p88.2255NM_005668
ST8SIA4hsa-miR-574-5p88.0373NM_175052
ST8SIA4hsa-miR-4731-3p87.8338NM_005668
ST8SIA4hsa-miR-94487.5966NM_175052
ST8SIA4hsa-miR-499a-5p87.512NM_175052
ST8SIA4hsa-miR-30b-5p87.0255NM_005668
ST8SIA4hsa-miR-30d-5p87.0255NM_005668
ST8SIA4hsa-miR-30c-5p87.0255NM_005668
ST8SIA4hsa-miR-30a-5p87.0255NM_005668
ST8SIA4hsa-miR-30e-5p87.0255NM_005668
ST8SIA4hsa-miR-477086.981NM_005668
ST8SIA4hsa-miR-318586.4592NM_175052
ST8SIA4hsa-miR-570-3p86.2243NM_005668
ST8SIA4hsa-miR-477585.6045NM_005668
ST8SIA4hsa-miR-426385.2535NM_175052
ST8SIA4hsa-miR-428284.9136NM_175052
ST8SIA4hsa-miR-9-5p84.8285NM_005668
ST8SIA4hsa-miR-373-5p84.4598NM_005668
ST8SIA4hsa-miR-371b-5p84.4598NM_005668
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Motifs and transcription factors (TFs) regulating ST8SIA4

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ST8SIA4jaspar__MA1956.1FOXO1 (directAnnotation).
ST8SIA4jaspar__MA1954.1FOXO1 (directAnnotation).
ST8SIA4tfdimers__MD00145ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).
ST8SIA4jaspar__MA1946.1FOXI1 (directAnnotation).
ST8SIA4tfdimers__MD00221FOXG1; FOXO1; GABPA (directAnnotation).
ST8SIA4taipale_tf_pairs__RFX3_SREBF2_NNRGYAACNTCACGTGAY_CAP_reprRFX3; SREBF2 (directAnnotation).
ST8SIA4jaspar__MA1955.1FOXO1 (directAnnotation).
ST8SIA4tfdimers__MD00204GABPA; NKX2-1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."