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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ST8SIA2

Summary for ST8SIA2

Gene information	Gene symbol	ST8SIA2
	Ensembl ID	ENSG00000140557
	Entrez ID	8128
	Gene name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
	Synonyms	HsT19690\|SIAT8B\|ST8SIA-II\|STX
	Gene type	protein_coding
	UniProtAcc	Q92186

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Dataset with differentially expressed gene: ST8SIA2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.308167	0.00e+00

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Expression of ST8SIA2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ST8SIA2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ST8SIA2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ST8SIA2	hsa-miR-5011-5p	99.71	NM_006011
ST8SIA2	hsa-miR-3134	94.9634	NM_006011
ST8SIA2	hsa-miR-9500	94.2961	NM_006011
ST8SIA2	hsa-miR-190a-3p	94.1345	NM_006011
ST8SIA2	hsa-miR-5683	91.7444	NM_006011
ST8SIA2	hsa-miR-6511a-5p	91.3402	NM_006011
ST8SIA2	hsa-miR-1910-3p	91.3402	NM_006011
ST8SIA2	hsa-miR-4292	90.5579	NM_006011
ST8SIA2	hsa-miR-6791-5p	90.5579	NM_006011
ST8SIA2	hsa-miR-510-5p	90.0155	NM_006011
ST8SIA2	hsa-miR-664a-3p	89.5879	NM_006011
ST8SIA2	hsa-miR-6815-3p	89.5218	NM_006011
ST8SIA2	hsa-miR-4291	89.2234	NM_006011
ST8SIA2	hsa-miR-3714	88.6122	NM_006011
ST8SIA2	hsa-miR-6752-3p	88.567	NM_006011
ST8SIA2	hsa-miR-1208	88.1431	NM_006011
ST8SIA2	hsa-miR-1236-3p	87.3134	NM_006011
ST8SIA2	hsa-miR-940	86.9982	NM_006011
ST8SIA2	hsa-miR-6808-5p	86.9982	NM_006011
ST8SIA2	hsa-miR-6893-5p	86.9982	NM_006011
ST8SIA2	hsa-miR-2467-3p	86.7769	NM_006011
ST8SIA2	hsa-miR-607	86.224	NM_006011
ST8SIA2	hsa-miR-4534	84.2874	NM_006011
ST8SIA2	hsa-miR-216a-5p	83.3232	NM_006011
ST8SIA2	hsa-miR-6811-3p	83.2245	NM_006011
ST8SIA2	hsa-miR-5692a	81.0006	NM_006011
ST8SIA2	hsa-miR-596	80.0256	NM_006011

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Motifs and transcription factors (TFs) regulating ST8SIA2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."