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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ST13

Summary for ST13

Gene information	Gene symbol	ST13
	Ensembl ID	ENSG00000100380
	Entrez ID	6767
	Gene name	ST13 Hsp70 interacting protein
	Synonyms	FAM10A1\|HIP\|HSPABP1\|P48\|SNC6
	Gene type	protein_coding
	UniProtAcc	P50502

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Dataset with differentially expressed gene: ST13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.468552	1.23e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.976553	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.297041	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.305927	1.17e-07
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.320017	1.68e-09
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	0.264361	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.276208	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.70287	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.57516	0.00e+00

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Expression of ST13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ST13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ST13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ST13	hsa-miR-6757-3p	97.2959	NM_001278589
ST13	hsa-miR-551b-5p	95.0291	NM_001278589
ST13	hsa-miR-1250-3p	92.4044	NM_001278589
ST13	hsa-miR-4310	92.1063	NM_001278589
ST13	hsa-miR-219a-1-3p	89.2781	NM_001278589
ST13	hsa-miR-4257	88.9711	NM_001278589
ST13	hsa-miR-7157-5p	88.546	NM_001278589
ST13	hsa-miR-4422	87.764	NM_001278589
ST13	hsa-miR-12136	87.1466	NM_001278589
ST13	hsa-miR-526b-5p	86.7025	NM_001278589
ST13	hsa-miR-6752-3p	86.6627	NM_001278589
ST13	hsa-miR-3133	85.7839	NM_001278589
ST13	hsa-miR-580-5p	85.3742	NM_001278589
ST13	hsa-miR-4470	84.8068	NM_001278589
ST13	hsa-miR-4698	84.4672	NM_001278589
ST13	hsa-miR-548az-5p	83.3264	NM_001278589
ST13	hsa-miR-548t-5p	83.3264	NM_001278589
ST13	hsa-miR-137-3p	83.2053	NM_001278589
ST13	hsa-miR-7853-5p	82.9557	NM_001278589
ST13	hsa-miR-105-5p	82.9557	NM_001278589
ST13	hsa-miR-9903	82.7843	NM_001278589
ST13	hsa-miR-5087	82.6884	NM_001278589
ST13	hsa-miR-1261	81.8879	NM_001278589
ST13	hsa-miR-3120-5p	81.7843	NM_001278589
ST13	hsa-miR-548c-3p	81.7548	NM_001278589
ST13	hsa-miR-5093	81.5844	NM_001278589
ST13	hsa-miR-570-3p	80.5495	NM_001278589
ST13	hsa-miR-5698	80.2924	NM_001278589
ST13	hsa-miR-7111-5p	80.2924	NM_001278589
ST13	hsa-miR-6870-5p	80.2924	NM_001278589
ST13	hsa-miR-4723-5p	80.2924	NM_001278589
ST13	hsa-miR-3662	80.1858	NM_001278589

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Motifs and transcription factors (TFs) regulating ST13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ST13	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
ST13	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
ST13	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ST13	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ST13	metacluster_101.3	MYB (directAnnotation).
ST13	hdpi__TP73	TP73 (directAnnotation).
ST13	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
ST13	transfac_pro__M06404	ZNF497 (directAnnotation).
ST13	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ST13	transfac_pro__M04826	EP300 (directAnnotation).
ST13	transfac_pro__M04748	GABPA (directAnnotation).
ST13	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
ST13	transfac_pro__M04844	MAX (directAnnotation).
ST13	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
ST13	metacluster_140.1	BCL11B; BCL11B (directAnnotation).
ST13	dbtfbs__ZNF610_HEK293_ENCSR691TXI_merged_N1	ZNF610 (directAnnotation).
ST13	taipale_cyt_meth__ELF3_NTGTGCGGATGCN_FL_repr	ELF3 (directAnnotation).
ST13	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
ST13	transfac_public__M00041	ATF2; JUN (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."