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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SSBP3

Summary for SSBP3

Gene information	Gene symbol	SSBP3
	Ensembl ID	ENSG00000157216
	Entrez ID	23648
	Gene name	single stranded DNA binding protein 3
	Synonyms	CSDP\|FLJ10355\|SSDP\|SSDP1
	Gene type	protein_coding
	UniProtAcc	Q9BWW4

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Dataset with differentially expressed gene: SSBP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.404446	8.47e-05
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.300271	0.00e+00

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Expression of SSBP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SSBP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SSBP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SSBP3	hsa-miR-4795-3p	98.5067	NM_001009955
SSBP3	hsa-miR-6785-5p	97.6486	NM_001009955
SSBP3	hsa-miR-4728-5p	97.6486	NM_001009955
SSBP3	hsa-miR-6883-5p	96.8474	NM_001009955
SSBP3	hsa-miR-149-3p	96.8474	NM_001009955
SSBP3	hsa-miR-12136	95.7133	NM_001009955
SSBP3	hsa-miR-6771-3p	95.6287	NM_001009955
SSBP3	hsa-miR-7-2-3p	94.0352	NM_001009955
SSBP3	hsa-miR-7-1-3p	94.0352	NM_001009955
SSBP3	hsa-miR-4738-3p	93.884	NM_001009955
SSBP3	hsa-miR-1285-5p	90.0904	NM_001009955
SSBP3	hsa-miR-2115-5p	89.8792	NM_001009955
SSBP3	hsa-miR-4692	89.4902	NM_001009955
SSBP3	hsa-miR-126-5p	88.4817	NM_001009955
SSBP3	hsa-miR-6756-5p	87.1252	NM_001009955
SSBP3	hsa-miR-6766-5p	87.1252	NM_001009955
SSBP3	hsa-miR-7111-3p	86.7495	NM_001009955
SSBP3	hsa-miR-6805-5p	86.724	NM_001009955
SSBP3	hsa-miR-4311	86.2017	NM_001009955
SSBP3	hsa-miR-4514	85.7886	NM_001009955
SSBP3	hsa-miR-3679-3p	83.8394	NM_001009955
SSBP3	hsa-miR-4422	81.2821	NM_001009955
SSBP3	hsa-miR-4651	81.2803	NM_001009955
SSBP3	hsa-miR-608	81.2803	NM_001009955
SSBP3	hsa-miR-2355-3p	81.1694	NM_001009955
SSBP3	hsa-miR-1248	80.4208	NM_001009955

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Motifs and transcription factors (TFs) regulating SSBP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SSBP3	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
SSBP3	cisbp__M00808	MYPOP (inferredBy_Orthology).
SSBP3	transfac_pro__M06404	ZNF497 (directAnnotation).
SSBP3	transfac_pro__M05815	ZNF613 (directAnnotation).
SSBP3	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
SSBP3	metacluster_155.28	ZFP64 (directAnnotation). ZFP64 (inferredBy_Orthology).
SSBP3	metacluster_136.3	MAX; MXI1; MXI1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX4; RFX5; RFX5; RFX5; SREBF1; ZBTB7B (directAnnotation). RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX6; RFX6; RFX6; RFX7; RFX8; RFX8 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."