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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SRSF6

Summary for SRSF6

Gene information	Gene symbol	SRSF6
	Ensembl ID	ENSG00000124193
	Entrez ID	6431
	Gene name	serine and arginine rich splicing factor 6
	Synonyms	B52\|SFRS6\|SRP55
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SRSF6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.256169	7.46e-09
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.250259	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.288305	1.87e-07
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.659678	0.00e+00

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Expression of SRSF6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SRSF6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SRSF6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SRSF6	hsa-miR-10527-5p	98.0251	NM_006275
SRSF6	hsa-miR-1283	97.5455	NM_006275
SRSF6	hsa-miR-10526-3p	97.0491	NM_006275
SRSF6	hsa-miR-5590-3p	95.5532	NM_006275
SRSF6	hsa-miR-142-5p	95.5532	NM_006275
SRSF6	hsa-miR-548l	95.0077	NM_006275
SRSF6	hsa-miR-548n	94.9595	NM_006275
SRSF6	hsa-miR-182-5p	93.9212	NM_006275
SRSF6	hsa-miR-506-3p	93.9172	NM_006275
SRSF6	hsa-miR-124-3p	93.9172	NM_006275
SRSF6	hsa-miR-4422	93.0077	NM_006275
SRSF6	hsa-miR-146a-5p	92.9949	NM_006275
SRSF6	hsa-miR-146b-5p	92.9949	NM_006275
SRSF6	hsa-miR-7153-5p	92.9949	NM_006275
SRSF6	hsa-miR-6835-3p	92.9698	NM_006275
SRSF6	hsa-miR-551b-5p	92.7847	NM_006275
SRSF6	hsa-miR-6768-5p	92.7461	NM_006275
SRSF6	hsa-miR-4291	92.2558	NM_006275
SRSF6	hsa-miR-19a-3p	92.1201	NM_006275
SRSF6	hsa-miR-19b-3p	92.1201	NM_006275
SRSF6	hsa-miR-3163	91.8951	NM_006275
SRSF6	hsa-miR-548av-5p	91.7429	NM_006275
SRSF6	hsa-miR-8054	91.7429	NM_006275
SRSF6	hsa-miR-548k	91.7429	NM_006275
SRSF6	hsa-miR-4701-5p	91.1568	NM_006275
SRSF6	hsa-miR-588	91.1568	NM_006275
SRSF6	hsa-miR-32-3p	90.8999	NM_006275
SRSF6	hsa-miR-4775	90.4571	NM_006275
SRSF6	hsa-miR-370-3p	90.3449	NM_006275
SRSF6	hsa-miR-6893-3p	90.3449	NM_006275
SRSF6	hsa-miR-3692-3p	90.1218	NM_006275
SRSF6	hsa-miR-548ad-5p	87.6062	NM_006275
SRSF6	hsa-miR-548y	87.6062	NM_006275
SRSF6	hsa-miR-548ak	87.6062	NM_006275
SRSF6	hsa-miR-548o-5p	87.6062	NM_006275
SRSF6	hsa-miR-548h-5p	87.6062	NM_006275
SRSF6	hsa-miR-548c-5p	87.6062	NM_006275
SRSF6	hsa-miR-548ae-5p	87.6062	NM_006275
SRSF6	hsa-miR-548ar-5p	87.6062	NM_006275
SRSF6	hsa-miR-548aq-5p	87.6062	NM_006275
SRSF6	hsa-miR-548w	87.6062	NM_006275
SRSF6	hsa-miR-548a-5p	87.6062	NM_006275
SRSF6	hsa-miR-548d-5p	87.6062	NM_006275
SRSF6	hsa-miR-548b-5p	87.6062	NM_006275
SRSF6	hsa-miR-548au-5p	87.6062	NM_006275
SRSF6	hsa-miR-548ay-5p	87.6062	NM_006275
SRSF6	hsa-miR-548bb-5p	87.6062	NM_006275
SRSF6	hsa-miR-548am-5p	87.6062	NM_006275
SRSF6	hsa-miR-548an	87.5835	NM_006275
SRSF6	hsa-miR-922	87.5338	NM_006275

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Motifs and transcription factors (TFs) regulating SRSF6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SRSF6	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
SRSF6	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
SRSF6	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
SRSF6	swissregulon__hs__ETV6	ETV6 (directAnnotation).
SRSF6	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
SRSF6	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
SRSF6	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
SRSF6	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
SRSF6	transfac_pro__M05956	BCL11B (directAnnotation).
SRSF6	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SRSF6	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SRSF6	cisbp__M08198	ELF1 (directAnnotation).
SRSF6	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SRSF6	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SRSF6	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."