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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SRP54

Summary for SRP54

Gene information	Gene symbol	SRP54
	Ensembl ID	ENSG00000100883
	Entrez ID	6729
	Gene name	signal recognition particle 54
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P61011

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Dataset with differentially expressed gene: SRP54

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.259184	3.02e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.17874	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.262168	2.12e-14

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Expression of SRP54 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SRP54

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SRP54

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SRP54	hsa-miR-4685-3p	97.4371	NM_001146282
SRP54	hsa-miR-4287	97.4371	NM_001146282
SRP54	hsa-miR-548d-3p	96.2529	NM_001146282
SRP54	hsa-miR-548ac	95.7899	NM_001146282
SRP54	hsa-miR-548bb-3p	95.7899	NM_001146282
SRP54	hsa-miR-548h-3p	95.7899	NM_001146282
SRP54	hsa-miR-548z	95.7899	NM_001146282
SRP54	hsa-miR-545-3p	91.8622	NM_001146282
SRP54	hsa-miR-4756-5p	91.6773	NM_001146282
SRP54	hsa-miR-1321	91.6773	NM_001146282
SRP54	hsa-miR-4739	91.6773	NM_001146282
SRP54	hsa-miR-3692-3p	91.4186	NM_001146282
SRP54	hsa-miR-629-3p	91.165	NM_001146282
SRP54	hsa-miR-4670-3p	90.4854	NM_001146282
SRP54	hsa-miR-4533	89.7847	NM_001146282
SRP54	hsa-miR-6787-3p	87.8604	NM_001146282
SRP54	hsa-miR-4767	86.0578	NM_001146282
SRP54	hsa-miR-6867-3p	86.0187	NM_001146282
SRP54	hsa-miR-1252-5p	85.7545	NM_001146282
SRP54	hsa-miR-651-3p	82.8807	NM_001146282
SRP54	hsa-miR-5702	81.5591	NM_001146282

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Motifs and transcription factors (TFs) regulating SRP54

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SRP54	transfac_pro__M06035	ZNF749 (directAnnotation).
SRP54	metacluster_52.11	ZNF184 (directAnnotation).
SRP54	metacluster_35.7	HINFP (inferredBy_Orthology).
SRP54	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SRP54	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SRP54	cisbp__M08198	ELF1 (directAnnotation).
SRP54	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
SRP54	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SRP54	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SRP54	hdpi__TP73	TP73 (directAnnotation).
SRP54	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
SRP54	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SRP54	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
SRP54	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
SRP54	transfac_pro__M04826	EP300 (directAnnotation).
SRP54	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SRP54	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
SRP54	transfac_pro__M04950	EGR1 (directAnnotation).
SRP54	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
SRP54	hdpi__FLI1	FLI1 (directAnnotation).
SRP54	transfac_pro__M04862	NRF1 (directAnnotation).
SRP54	jaspar__MA1708.1	ETV7 (directAnnotation).
SRP54	transfac_pro__M00652	NRF1 (directAnnotation).
SRP54	metacluster_55.5	ZNF541 (directAnnotation).
SRP54	swissregulon__hs__ETV6	ETV6 (directAnnotation).
SRP54	cisbp__M02645	ETS1 (directAnnotation).
SRP54	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
SRP54	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
SRP54	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
SRP54	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SRP54	hdpi__ETV4	ETV4 (directAnnotation).
SRP54	transfac_pro__M00492	STAT1 (directAnnotation).
SRP54	metacluster_135.11	NR2C2 (directAnnotation).
SRP54	metacluster_7.13	ZFX (directAnnotation).
SRP54	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SRP54	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SRP54	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SRP54	cisbp__M00788	ZFY (inferredBy_Orthology).
SRP54	hdpi__ZNF304	ZNF304 (directAnnotation).
SRP54	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SRP54	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SRP54	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SRP54	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SRP54	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."