Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SRI

Summary for SRI

Gene information	Gene symbol	SRI
	Ensembl ID	ENSG00000075142
	Entrez ID	6717
	Gene name	sorcin
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P30626

Top

Dataset with differentially expressed gene: SRI

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.45657	2.34e-40
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.272704	5.79e-14
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.458356	7.59e-22
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.738898	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.410504	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.26626	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.679095	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.288466	1.17e-20
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.316102	3.74e-15
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.92846	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.315084	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.35099	0.00e+00

Top

Expression of SRI in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SRI

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SRI	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating SRI

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SRI	hsa-miR-3646	95.5654	NM_001256891
SRI	hsa-miR-12123	93.2989	NM_001256891
SRI	hsa-miR-206	92.6482	NM_198901
SRI	hsa-miR-1-3p	92.6482	NM_198901
SRI	hsa-miR-493-5p	91.9743	NM_003130
SRI	hsa-miR-7161-3p	91.7745	NM_003130
SRI	hsa-miR-1323	91.391	NM_198901
SRI	hsa-miR-613	91.2711	NM_198901
SRI	hsa-miR-7856-5p	90.9124	NM_003130
SRI	hsa-miR-548o-3p	89.8963	NM_198901
SRI	hsa-miR-451b	89.2065	NM_003130
SRI	hsa-miR-3658	87.4102	NM_003130
SRI	hsa-miR-549a-3p	86.0705	NM_003130
SRI	hsa-miR-33a-3p	84.3525	NM_003130
SRI	hsa-miR-9851-5p	84.2839	NM_003130
SRI	hsa-miR-16-1-3p	84.2598	NM_003130
SRI	hsa-miR-559	83.9539	NM_198901
SRI	hsa-miR-499a-5p	83.6837	NM_001256891
SRI	hsa-miR-29a-5p	82.9844	NM_003130
SRI	hsa-miR-200c-3p	82.6403	NM_003130
SRI	hsa-miR-429	82.6403	NM_003130
SRI	hsa-miR-200b-3p	82.6403	NM_003130
SRI	hsa-miR-4698	81.6774	NM_198901
SRI	hsa-miR-6796-3p	81.6048	NM_003130
SRI	hsa-miR-3920	81.3193	NM_003130
SRI	hsa-miR-4790-3p	81.0906	NM_003130
SRI	hsa-miR-148a-5p	80.7119	NM_198901
SRI	hsa-miR-6858-3p	80.6802	NM_003130
SRI	hsa-miR-223-5p	80.3527	NM_003130
SRI	hsa-miR-3680-3p	80.1263	NM_003130
SRI	hsa-miR-3613-5p	80.0872	NM_003130

Page: 1

Top

Motifs and transcription factors (TFs) regulating SRI

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SRI	metacluster_172.23	ZBTB32; ZBTB32 (directAnnotation).
SRI	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SRI	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SRI	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SRI	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SRI	transfac_pro__M00652	NRF1 (directAnnotation).
SRI	transfac_pro__M04866	HDAC2 (directAnnotation).
SRI	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SRI	metacluster_44.20	NKX3-1 (directAnnotation).
SRI	metacluster_44.19	NKX3-1 (inferredBy_Orthology).
SRI	metacluster_44.21	NKX3-2 (directAnnotation).
SRI	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
SRI	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
SRI	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
SRI	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SRI	transfac_pro__M06833	PEG3 (directAnnotation).
SRI	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
SRI	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SRI	transfac_pro__M06032	ZNF727 (directAnnotation).
SRI	cisbp__M02645	ETS1 (directAnnotation).
SRI	transfac_pro__M06405	ZNF329 (directAnnotation).
SRI	metacluster_161.16	NKX3-2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SRI	"Calcium citrate"	DB11093	small molecule
SRI	"Calcium phosphate dihydrate"	DB14481	small molecule
SRI	"Calcium Phosphate"	DB11348	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."