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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SRGAP1

Summary for SRGAP1

Gene information	Gene symbol	SRGAP1
	Ensembl ID	ENSG00000196935
	Entrez ID	57522
	Gene name	SLIT-ROBO Rho GTPase activating protein 1
	Synonyms	ARHGAP13\|KIAA1304
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SRGAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.773876	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.271555	1.92e-29
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.250887	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.28941	0.00e+00

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Expression of SRGAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SRGAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SRGAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SRGAP1	hsa-miR-5195-3p	99.8504	NM_020762
SRGAP1	hsa-miR-145-5p	99.7398	NM_020762
SRGAP1	hsa-miR-124-3p	95.5457	NM_020762
SRGAP1	hsa-miR-506-3p	95.5457	NM_020762
SRGAP1	hsa-miR-340-5p	93.9204	NM_020762
SRGAP1	hsa-miR-4500	92.7203	NM_020762
SRGAP1	hsa-miR-3944-5p	92.5918	NM_020762
SRGAP1	hsa-miR-4521	92.1246	NM_020762
SRGAP1	hsa-miR-4478	91.9997	NM_020762
SRGAP1	hsa-miR-664b-3p	91.8956	NM_020762
SRGAP1	hsa-miR-579-3p	91.8956	NM_020762
SRGAP1	hsa-miR-1305	91.7322	NM_020762
SRGAP1	hsa-miR-302d-5p	91.5898	NM_020762
SRGAP1	hsa-miR-302b-5p	91.5898	NM_020762
SRGAP1	hsa-miR-3074-5p	91.4123	NM_020762
SRGAP1	hsa-miR-1290	91.3666	NM_020762
SRGAP1	hsa-miR-548an	91.2346	NM_020762
SRGAP1	hsa-miR-651-3p	90.9681	NM_020762
SRGAP1	hsa-miR-4458	90.8082	NM_020762
SRGAP1	hsa-let-7d-5p	90.8082	NM_020762
SRGAP1	hsa-miR-3925-3p	90.615	NM_020762
SRGAP1	hsa-let-7g-5p	90.3935	NM_020762
SRGAP1	hsa-miR-98-5p	90.3935	NM_020762
SRGAP1	hsa-let-7c-5p	90.3935	NM_020762
SRGAP1	hsa-let-7e-5p	90.3935	NM_020762
SRGAP1	hsa-let-7i-5p	90.3935	NM_020762
SRGAP1	hsa-let-7b-5p	90.3935	NM_020762
SRGAP1	hsa-let-7a-5p	90.3935	NM_020762
SRGAP1	hsa-let-7f-5p	90.3935	NM_020762
SRGAP1	hsa-miR-11401	89.8578	NM_020762
SRGAP1	hsa-miR-493-5p	89.7261	NM_020762
SRGAP1	hsa-miR-20a-5p	89.2126	NM_020762
SRGAP1	hsa-miR-106b-5p	89.2126	NM_020762
SRGAP1	hsa-miR-519b-3p	88.8984	NM_020762
SRGAP1	hsa-miR-519a-3p	88.8984	NM_020762
SRGAP1	hsa-miR-519c-3p	88.8984	NM_020762
SRGAP1	hsa-miR-1297	88.808	NM_020762
SRGAP1	hsa-miR-526b-3p	88.7154	NM_020762
SRGAP1	hsa-miR-20b-5p	88.7154	NM_020762
SRGAP1	hsa-miR-106a-5p	88.7154	NM_020762
SRGAP1	hsa-miR-519d-3p	88.7154	NM_020762
SRGAP1	hsa-miR-17-5p	88.7154	NM_020762
SRGAP1	hsa-miR-93-5p	88.7154	NM_020762
SRGAP1	hsa-miR-1323	88.3876	NM_020762
SRGAP1	hsa-miR-548o-3p	88.3876	NM_020762
SRGAP1	hsa-miR-4263	88.2033	NM_020762
SRGAP1	hsa-miR-198	87.7742	NM_020762
SRGAP1	hsa-miR-6854-5p	87.3825	NM_020762
SRGAP1	hsa-miR-200b-3p	87.1433	NM_020762
SRGAP1	hsa-miR-429	87.1433	NM_020762

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Motifs and transcription factors (TFs) regulating SRGAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SRGAP1	metacluster_7.13	ZFX (directAnnotation).
SRGAP1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SRGAP1	metacluster_151.2	ZNF23 (directAnnotation).
SRGAP1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SRGAP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SRGAP1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SRGAP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SRGAP1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SRGAP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SRGAP1	jaspar__MA0079.5	SP1 (directAnnotation).
SRGAP1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SRGAP1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SRGAP1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SRGAP1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
SRGAP1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SRGAP1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
SRGAP1	metacluster_3.14	WT1; WT1 (directAnnotation).
SRGAP1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SRGAP1	cisbp__M07938	E2F1 (directAnnotation).
SRGAP1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SRGAP1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
SRGAP1	transfac_pro__M04950	EGR1 (directAnnotation).
SRGAP1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SRGAP1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SRGAP1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SRGAP1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
SRGAP1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SRGAP1	transfac_pro__M00652	NRF1 (directAnnotation).
SRGAP1	transfac_pro__M04866	HDAC2 (directAnnotation).
SRGAP1	jaspar__MA1122.1	TFDP1 (directAnnotation).
SRGAP1	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."