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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SRF

Summary for SRF

Gene information	Gene symbol	SRF
	Ensembl ID	ENSG00000112658
	Entrez ID	6722
	Gene name	serum response factor
	Synonyms	MCM1
	Gene type	protein_coding
	UniProtAcc	P11831

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Dataset with differentially expressed gene: SRF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.318249	1.34e-06

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Expression of SRF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SRF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SRF	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SRF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SRF	hsa-miR-196a-3p	97.4042	NM_001292001
SRF	hsa-miR-5698	97.0107	NM_003131
SRF	hsa-miR-4279	96.9203	NM_001292001
SRF	hsa-miR-7111-5p	96.8677	NM_003131
SRF	hsa-miR-6870-5p	96.6555	NM_003131
SRF	hsa-miR-4723-5p	95.8015	NM_003131
SRF	hsa-miR-6729-3p	94.692	NM_001292001
SRF	hsa-miR-122-3p	94.5106	NM_003131
SRF	hsa-miR-12136	94.3692	NM_003131
SRF	hsa-miR-4746-5p	94.318	NM_001292001
SRF	hsa-miR-6840-3p	94.2777	NM_003131
SRF	hsa-miR-5196-5p	94.1631	NM_003131
SRF	hsa-miR-4747-5p	94.1631	NM_003131
SRF	hsa-miR-891a-3p	93.9522	NM_001292001
SRF	hsa-miR-655-3p	93.7285	NM_003131
SRF	hsa-miR-374c-5p	93.7285	NM_003131
SRF	hsa-miR-6867-5p	92.9307	NM_003131
SRF	hsa-miR-6842-3p	92.9039	NM_001292001
SRF	hsa-miR-95-5p	92.2589	NM_001292001
SRF	hsa-miR-4732-3p	90.7561	NM_001292001
SRF	hsa-miR-6764-5p	89.4777	NM_003131
SRF	hsa-miR-548an	88.9422	NM_003131
SRF	hsa-miR-4667-3p	88.5253	NM_001292001
SRF	hsa-miR-3688-5p	87.7325	NM_001292001
SRF	hsa-miR-6721-5p	87.3725	NM_001292001
SRF	hsa-miR-647	86.882	NM_001292001
SRF	hsa-miR-8485	86.8485	NM_003131
SRF	hsa-miR-335-5p	86.7079	NM_003131
SRF	hsa-miR-6749-3p	86.489	NM_001292001
SRF	hsa-miR-1915-3p	85.9126	NM_003131
SRF	hsa-miR-6825-5p	85.6951	NM_003131
SRF	hsa-miR-4319	84.7055	NM_001292001
SRF	hsa-miR-4758-3p	84.5508	NM_001292001
SRF	hsa-miR-511-5p	83.3898	NM_003131
SRF	hsa-miR-10401-5p	83.2517	NM_003131
SRF	hsa-miR-4470	83.0259	NM_001292001
SRF	hsa-miR-3179	82.8756	NM_003131
SRF	hsa-miR-1207-3p	82.4808	NM_001292001
SRF	hsa-miR-10398-5p	82.0554	NM_001292001
SRF	hsa-miR-6794-5p	81.6989	NM_003131
SRF	hsa-miR-4716-3p	80.8769	NM_003131
SRF	hsa-miR-6756-5p	80.7795	NM_003131
SRF	hsa-miR-6766-5p	80.7795	NM_003131
SRF	hsa-miR-6814-5p	80.6658	NM_001292001
SRF	hsa-miR-125a-5p	80.6322	NM_001292001
SRF	hsa-miR-125b-5p	80.6322	NM_001292001
SRF	hsa-miR-670-5p	80.4949	NM_001292001
SRF	hsa-miR-5011-5p	80.2003	NM_003131

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Motifs and transcription factors (TFs) regulating SRF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SRF	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SRF	metacluster_198.3	ZFP64 (directAnnotation).
SRF	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."