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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SREK1IP1

Summary for SREK1IP1

Gene information	Gene symbol	SREK1IP1
	Ensembl ID	ENSG00000153006
	Entrez ID	285672
	Gene name	SREK1 interacting protein 1
	Synonyms	FLJ36754\|P18SRP\|SFRS12IP1
	Gene type	protein_coding
	UniProtAcc	Q8N9Q2

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Dataset with differentially expressed gene: SREK1IP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.367949	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.326841	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.306475	1.40e-37
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.267404	3.37e-25
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.523169	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.480872	1.97e-25
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.517201	5.78e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.285289	1.32e-24

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Expression of SREK1IP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SREK1IP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SREK1IP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SREK1IP1	hsa-miR-4282	98.8411	NM_173829
SREK1IP1	hsa-miR-183-5p	96.7545	NM_173829
SREK1IP1	hsa-miR-3163	95.501	NM_173829
SREK1IP1	hsa-miR-944	95.0317	NM_173829
SREK1IP1	hsa-miR-548c-3p	93.9566	NM_173829
SREK1IP1	hsa-miR-5696	93.5839	NM_173829
SREK1IP1	hsa-miR-4482-3p	92.3933	NM_173829
SREK1IP1	hsa-miR-548x-3p	91.8736	NM_173829
SREK1IP1	hsa-miR-548aj-3p	91.8736	NM_173829
SREK1IP1	hsa-miR-5009-3p	91.5071	NM_173829
SREK1IP1	hsa-miR-5582-3p	91.1867	NM_173829
SREK1IP1	hsa-miR-7-1-3p	90.1758	NM_173829
SREK1IP1	hsa-miR-7-2-3p	90.1758	NM_173829
SREK1IP1	hsa-miR-527	90.1592	NM_173829
SREK1IP1	hsa-miR-518a-5p	90.1592	NM_173829
SREK1IP1	hsa-miR-216b-5p	89.6617	NM_173829
SREK1IP1	hsa-miR-4729	89.5819	NM_173829
SREK1IP1	hsa-miR-568	89.539	NM_173829
SREK1IP1	hsa-miR-5692a	89.2255	NM_173829
SREK1IP1	hsa-miR-202-3p	88.9628	NM_173829
SREK1IP1	hsa-miR-548ah-3p	88.8441	NM_173829
SREK1IP1	hsa-miR-548aq-3p	88.8441	NM_173829
SREK1IP1	hsa-miR-548ae-3p	88.8441	NM_173829
SREK1IP1	hsa-miR-548am-3p	88.8441	NM_173829
SREK1IP1	hsa-miR-548j-3p	88.8441	NM_173829
SREK1IP1	hsa-miR-8067	88.6981	NM_173829
SREK1IP1	hsa-miR-4294	88.3018	NM_173829
SREK1IP1	hsa-miR-9-3p	87.4445	NM_173829
SREK1IP1	hsa-miR-95-5p	85.3587	NM_173829
SREK1IP1	hsa-miR-376b-3p	84.7296	NM_173829
SREK1IP1	hsa-miR-376a-3p	84.7296	NM_173829
SREK1IP1	hsa-miR-6508-5p	84.1148	NM_173829
SREK1IP1	hsa-miR-506-5p	84.0216	NM_173829
SREK1IP1	hsa-miR-190a-3p	83.2093	NM_173829
SREK1IP1	hsa-miR-935	83.1925	NM_173829
SREK1IP1	hsa-miR-4793-3p	82.9253	NM_173829
SREK1IP1	hsa-miR-421	82.1324	NM_173829
SREK1IP1	hsa-miR-4797-3p	81.2126	NM_173829
SREK1IP1	hsa-miR-338-5p	81.1945	NM_173829
SREK1IP1	hsa-miR-4264	80.9335	NM_173829
SREK1IP1	hsa-miR-335-5p	80.8658	NM_173829
SREK1IP1	hsa-miR-8076	80.7614	NM_173829
SREK1IP1	hsa-miR-548aw	80.4865	NM_173829
SREK1IP1	hsa-miR-544a	80.3109	NM_173829

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Motifs and transcription factors (TFs) regulating SREK1IP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SREK1IP1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
SREK1IP1	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
SREK1IP1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
SREK1IP1	transfac_pro__M04862	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."