Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SREK1

Summary for SREK1

Gene information	Gene symbol	SREK1
	Ensembl ID	ENSG00000153914
	Entrez ID	140890
	Gene name	splicing regulatory glutamic acid and lysine rich protein 1
	Synonyms	DKFZp564B176\|SFRS12\|SRrp508\|SRrp86
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: SREK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.387478	2.11e-21
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.254492	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.370296	7.23e-17
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.253433	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.322354	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.295176	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.406665	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.623028	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.396753	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.473439	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.311284	0.00e+00

Top

Expression of SREK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SREK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SREK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SREK1	hsa-miR-4503	99.8515	NM_001323533
SREK1	hsa-miR-570-3p	99.2652	NM_001323533
SREK1	hsa-miR-1250-3p	98.747	NM_001323533
SREK1	hsa-miR-153-5p	98.6133	NM_001323533
SREK1	hsa-miR-590-3p	98.5713	NM_001077199
SREK1	hsa-miR-6792-5p	98.3878	NM_001323533
SREK1	hsa-miR-4282	97.7837	NM_001077199
SREK1	hsa-miR-15b-5p	97.7407	NM_001077199
SREK1	hsa-miR-195-5p	97.7407	NM_001077199
SREK1	hsa-miR-15a-5p	97.7407	NM_001077199
SREK1	hsa-miR-16-5p	97.7407	NM_001077199
SREK1	hsa-miR-4477a	97.5706	NM_001323533
SREK1	hsa-miR-548n	97.4773	NM_001077199
SREK1	hsa-miR-5692a	96.6296	NM_001323533
SREK1	hsa-miR-6838-5p	96.4956	NM_001077199
SREK1	hsa-miR-424-5p	96.4956	NM_001077199
SREK1	hsa-miR-497-5p	96.4956	NM_001077199
SREK1	hsa-miR-5093	96.3571	NM_001077199
SREK1	hsa-miR-7856-5p	95.739	NM_001077199
SREK1	hsa-miR-3059-5p	95.5637	NM_001323533
SREK1	hsa-miR-5688	95.0586	NM_001077199
SREK1	hsa-miR-495-3p	94.677	NM_001077199
SREK1	hsa-miR-6512-5p	94.0138	NM_001323533
SREK1	hsa-miR-549a-3p	93.3861	NM_001077199
SREK1	hsa-miR-651-3p	93.0515	NM_001077199
SREK1	hsa-miR-2115-5p	92.9776	NM_001323533
SREK1	hsa-miR-218-5p	92.775	NM_001323533
SREK1	hsa-miR-3662	92.4601	NM_001077199
SREK1	hsa-miR-3658	92.3962	NM_001077199
SREK1	hsa-miR-186-5p	91.9536	NM_001323533
SREK1	hsa-miR-506-3p	91.7277	NM_001323533
SREK1	hsa-miR-124-3p	91.7277	NM_001323533
SREK1	hsa-miR-2115-3p	91.5179	NM_001077199
SREK1	hsa-miR-3133	91.3927	NM_001323533
SREK1	hsa-miR-670-3p	90.9129	NM_001323533
SREK1	hsa-miR-548ax	89.1616	NM_001077199
SREK1	hsa-miR-548ao-5p	89.1616	NM_001077199
SREK1	hsa-miR-646	88.6908	NM_001323533
SREK1	hsa-miR-498-5p	88.6121	NM_001077199
SREK1	hsa-miR-513c-3p	88.3661	NM_001323533
SREK1	hsa-miR-513a-3p	88.3661	NM_001323533
SREK1	hsa-miR-128-3p	88.3511	NM_001077199
SREK1	hsa-miR-216a-3p	88.3511	NM_001077199
SREK1	hsa-miR-4302	88.3405	NM_001077199
SREK1	hsa-miR-4524a-5p	88.0707	NM_001077199
SREK1	hsa-miR-4999-5p	87.9498	NM_001323533
SREK1	hsa-miR-107	87.8277	NM_001323533
SREK1	hsa-miR-103a-3p	87.8277	NM_001323533
SREK1	hsa-miR-6508-5p	87.5443	NM_001077199
SREK1	hsa-miR-12123	87.484	NM_001077199

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating SREK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SREK1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SREK1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SREK1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SREK1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SREK1	transfac_pro__M02090	E2F4 (directAnnotation).
SREK1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
SREK1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SREK1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
SREK1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SREK1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SREK1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SREK1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
SREK1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SREK1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
SREK1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SREK1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
SREK1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SREK1	cisbp__M08198	ELF1 (directAnnotation).
SREK1	transfac_pro__M00652	NRF1 (directAnnotation).
SREK1	hdpi__ETV4	ETV4 (directAnnotation).
SREK1	transfac_pro__M04866	HDAC2 (directAnnotation).
SREK1	jaspar__MA1122.1	TFDP1 (directAnnotation).
SREK1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
SREK1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SREK1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
SREK1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SREK1	jaspar__MA0748.2	YY2 (directAnnotation).
SREK1	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
SREK1	hdpi__EBF1	EBF1 (directAnnotation).
SREK1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
SREK1	taipale_tf_pairs__E2F3_EOMES_NNGYGNNNNGGCGCSNNNNCRCNN_CAP_repr	E2F3; EOMES (directAnnotation).
SREK1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SREK1	cisbp__M02645	ETS1 (directAnnotation).
SREK1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
SREK1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
SREK1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
SREK1	transfac_pro__M01298	MECP2 (directAnnotation).
SREK1	transfac_pro__M00492	STAT1 (directAnnotation).
SREK1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
SREK1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SREK1	transfac_pro__M00430	E2F1 (directAnnotation).
SREK1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
SREK1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
SREK1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SREK1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
SREK1	metacluster_191.5	SPDEF (inferredBy_Orthology).
SREK1	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
SREK1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
SREK1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
SREK1	hdpi__RARA	RARA (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."