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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: SREBF2

Summary for SREBF2

Gene information	Gene symbol	SREBF2
	Ensembl ID	ENSG00000198911
	Entrez ID	6721
	Gene name	sterol regulatory element binding transcription factor 2
	Synonyms	bHLHd2\|SREBP2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SREBF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.50878	2.23e-13
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.391435	7.75e-43
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.280841	9.28e-19

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Expression of SREBF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SREBF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SREBF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SREBF2	hsa-miR-6764-5p	95.9498	NM_004599
SREBF2	hsa-miR-1915-3p	95.0652	NM_004599
SREBF2	hsa-miR-6785-5p	92.8487	NM_004599
SREBF2	hsa-miR-149-3p	92.8487	NM_004599
SREBF2	hsa-miR-4728-5p	92.8487	NM_004599
SREBF2	hsa-miR-6883-5p	92.8487	NM_004599
SREBF2	hsa-miR-8085	92.5744	NM_004599
SREBF2	hsa-miR-6731-5p	92.5744	NM_004599
SREBF2	hsa-miR-4293	91.1033	NM_004599
SREBF2	hsa-miR-4306	89.1799	NM_004599
SREBF2	hsa-miR-6797-5p	88.7707	NM_004599
SREBF2	hsa-miR-1249-5p	87.1456	NM_004599
SREBF2	hsa-miR-6825-5p	85.108	NM_004599
SREBF2	hsa-miR-185-5p	82.2596	NM_004599
SREBF2	hsa-miR-4644	82.2596	NM_004599
SREBF2	hsa-miR-570-3p	82.2287	NM_004599

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Motifs and transcription factors (TFs) regulating SREBF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SREBF2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SREBF2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SREBF2	transfac_pro__M07387	ZBTB7A (directAnnotation).
SREBF2	transfac_pro__M00716	ZBTB14 (directAnnotation).
SREBF2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SREBF2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SREBF2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SREBF2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
SREBF2	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
SREBF2	transfac_pro__M06104	ZNF16 (directAnnotation).
SREBF2	metacluster_22.28	BACH1 (directAnnotation).
SREBF2	jaspar__MA1562.1	SOX14 (directAnnotation).
SREBF2	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
SREBF2	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
SREBF2	cisbp__M01725	down	Malignant cells	GSE131984_Pac	NA
SREBF2	metacluster_57.3	down	Malignant cells	GSE131984_Pac	NA
SREBF2	jaspar__MA1933.1	down	Malignant cells	GSE131984_Pac	NA
SREBF2	jaspar__MA1933.1	up	Malignant cells	GSE186960	NA
SREBF2	jaspar__MA1933.1	up	Malignant cells	GSE186960	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."