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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SPTLC3

Summary for SPTLC3

Gene information	Gene symbol	SPTLC3
	Ensembl ID	ENSG00000172296
	Entrez ID	55304
	Gene name	serine palmitoyltransferase long chain base subunit 3
	Synonyms	C20orf38\|FLJ11112\|hLCB2b\|LCB2B\|SPTLC2L
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SPTLC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.939746	0.00e+00

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Expression of SPTLC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPTLC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPTLC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPTLC3	hsa-miR-6867-5p	99.8691	NM_018327
SPTLC3	hsa-miR-587	96.7868	NM_018327
SPTLC3	hsa-miR-8063	95.1104	NM_018327
SPTLC3	hsa-miR-4504	92.7007	NM_018327
SPTLC3	hsa-miR-3616-5p	92.3742	NM_018327
SPTLC3	hsa-miR-573	92.3742	NM_018327
SPTLC3	hsa-miR-664b-3p	90.9503	NM_018327
SPTLC3	hsa-miR-579-3p	90.9503	NM_018327
SPTLC3	hsa-miR-448	87.3412	NM_018327
SPTLC3	hsa-miR-586	87.2453	NM_018327
SPTLC3	hsa-miR-425-5p	87.1761	NM_018327
SPTLC3	hsa-miR-4698	87.0653	NM_018327
SPTLC3	hsa-miR-890	85.1054	NM_018327
SPTLC3	hsa-miR-4316	83.7772	NM_018327
SPTLC3	hsa-miR-3916	82.3568	NM_018327
SPTLC3	hsa-miR-6859-5p	82.3568	NM_018327
SPTLC3	hsa-miR-3125	82.3568	NM_018327
SPTLC3	hsa-miR-4520-2-3p	81.8698	NM_018327
SPTLC3	hsa-miR-6830-3p	81.6388	NM_018327
SPTLC3	hsa-miR-4469	81.3772	NM_018327
SPTLC3	hsa-miR-6770-5p	80.0727	NM_018327

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Motifs and transcription factors (TFs) regulating SPTLC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPTLC3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SPTLC3	"Pyridoxal phosphate"	DB00114	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."