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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPTBN4

Summary for SPTBN4

Gene information	Gene symbol	SPTBN4
	Ensembl ID	ENSG00000160460
	Entrez ID	57731
	Gene name	spectrin beta, non-erythrocytic 4
	Synonyms	KIAA1642\|SPTBN3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SPTBN4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.642126	4.11e-02

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Expression of SPTBN4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPTBN4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPTBN4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPTBN4	hsa-miR-6887-3p	99.6601	NM_020971
SPTBN4	hsa-miR-450b-5p	95.6336	NM_020971
SPTBN4	hsa-miR-608	94.87	NM_020971
SPTBN4	hsa-miR-448	94.7639	NM_020971
SPTBN4	hsa-miR-153-3p	94.7639	NM_020971
SPTBN4	hsa-miR-6826-3p	94.7169	NM_020971
SPTBN4	hsa-miR-4651	92.6491	NM_020971
SPTBN4	hsa-miR-548aw	91.3511	NM_020971
SPTBN4	hsa-miR-507	90.7354	NM_020971
SPTBN4	hsa-miR-3680-3p	90.7354	NM_020971
SPTBN4	hsa-miR-557	90.4321	NM_020971
SPTBN4	hsa-miR-92b-3p	89.543	NM_020971
SPTBN4	hsa-miR-92a-3p	89.543	NM_020971
SPTBN4	hsa-miR-32-5p	89.543	NM_020971
SPTBN4	hsa-miR-6722-3p	89.2139	NM_020971
SPTBN4	hsa-miR-25-3p	88.1075	NM_020971
SPTBN4	hsa-miR-363-3p	88.1075	NM_020971
SPTBN4	hsa-miR-367-3p	88.1075	NM_020971
SPTBN4	hsa-miR-4664-5p	87.0927	NM_020971
SPTBN4	hsa-miR-4650-5p	86.6888	NM_025213
SPTBN4	hsa-miR-5699-3p	86.3278	NM_025213
SPTBN4	hsa-miR-760	86.0935	NM_020971
SPTBN4	hsa-miR-6795-3p	85.0585	NM_020971
SPTBN4	hsa-miR-765	84.8861	NM_020971
SPTBN4	hsa-miR-1294	81.8775	NM_020971
SPTBN4	hsa-miR-9986	81.8775	NM_020971
SPTBN4	hsa-miR-6825-5p	81.7015	NM_020971
SPTBN4	hsa-miR-1909-3p	80.6482	NM_020971
SPTBN4	hsa-miR-11181-3p	80.5217	NM_020971

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Motifs and transcription factors (TFs) regulating SPTBN4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."