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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPPL3

Summary for SPPL3

Gene information	Gene symbol	SPPL3
	Ensembl ID	ENSG00000157837
	Entrez ID	121665
	Gene name	signal peptide peptidase like 3
	Synonyms	DKFZP586C1324\|IMP2\|MGC126674\|MGC126676\|MGC90402\|PSL4
	Gene type	protein_coding
	UniProtAcc	Q8TCT6

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Dataset with differentially expressed gene: SPPL3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.262974	1.76e-18
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.375268	0.00e+00

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Expression of SPPL3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPPL3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPPL3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPPL3	hsa-miR-5011-5p	99.9384	NM_139015
SPPL3	hsa-miR-190a-3p	99.618	NM_139015
SPPL3	hsa-miR-3613-3p	98.7462	NM_139015
SPPL3	hsa-miR-8056	97.1498	NM_139015
SPPL3	hsa-miR-4255	97.0547	NM_139015
SPPL3	hsa-miR-7114-5p	96.9454	NM_139015
SPPL3	hsa-miR-7152-3p	95.5508	NM_139015
SPPL3	hsa-miR-4277	95.1709	NM_139015
SPPL3	hsa-miR-3529-3p	95.123	NM_139015
SPPL3	hsa-miR-124-5p	93.927	NM_139015
SPPL3	hsa-miR-3121-3p	93.2862	NM_139015
SPPL3	hsa-miR-132-3p	92.7581	NM_139015
SPPL3	hsa-miR-212-3p	92.7581	NM_139015
SPPL3	hsa-miR-12123	92.2437	NM_139015
SPPL3	hsa-miR-4752	91.9339	NM_139015
SPPL3	hsa-miR-6867-5p	91.4737	NM_139015
SPPL3	hsa-miR-6888-3p	91.3788	NM_139015
SPPL3	hsa-miR-122b-5p	91.2373	NM_139015
SPPL3	hsa-miR-671-5p	90.3062	NM_139015
SPPL3	hsa-miR-3120-5p	88.8641	NM_139015
SPPL3	hsa-miR-3065-5p	88.0901	NM_139015
SPPL3	hsa-miR-6890-3p	86.2217	NM_139015
SPPL3	hsa-miR-4328	86.1949	NM_139015
SPPL3	hsa-miR-876-5p	86.0334	NM_139015
SPPL3	hsa-miR-3691-5p	85.2771	NM_139015
SPPL3	hsa-miR-3167	84.9364	NM_139015
SPPL3	hsa-miR-5010-3p	84.7521	NM_139015
SPPL3	hsa-miR-134-3p	84.6379	NM_139015
SPPL3	hsa-miR-584-3p	84.3939	NM_139015
SPPL3	hsa-miR-494-3p	84.3013	NM_139015
SPPL3	hsa-miR-766-3p	83.7473	NM_139015
SPPL3	hsa-miR-6165	82.8922	NM_139015
SPPL3	hsa-miR-6770-5p	82.4475	NM_139015
SPPL3	hsa-miR-300	81.1162	NM_139015
SPPL3	hsa-miR-381-3p	81.1162	NM_139015
SPPL3	hsa-miR-3619-5p	80.5016	NM_139015
SPPL3	hsa-miR-568	80.4999	NM_139015
SPPL3	hsa-miR-4775	80.4968	NM_139015
SPPL3	hsa-miR-4501	80.3918	NM_139015
SPPL3	hsa-miR-4729	80.1069	NM_139015

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Motifs and transcription factors (TFs) regulating SPPL3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPPL3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SPPL3	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
SPPL3	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SPPL3	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
SPPL3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SPPL3	metacluster_3.14	WT1; WT1 (directAnnotation).
SPPL3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SPPL3	cisbp__M07938	E2F1 (directAnnotation).
SPPL3	metacluster_135.11	NR2C2 (directAnnotation).
SPPL3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SPPL3	metacluster_7.13	ZFX (directAnnotation).
SPPL3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SPPL3	cisbp__M00968	MTF2 (directAnnotation).
SPPL3	cisbp__M00341	PAX6 (directAnnotation).
SPPL3	metacluster_198.3	ZFP64 (directAnnotation).
SPPL3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SPPL3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SPPL3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SPPL3	cisbp__M00788	ZFY (inferredBy_Orthology).
SPPL3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SPPL3	metacluster_175.1	ZNF283 (directAnnotation).
SPPL3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SPPL3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SPPL3	metacluster_151.2	ZNF23 (directAnnotation).
SPPL3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SPPL3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SPPL3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."