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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPPL2A

Summary for SPPL2A

Gene information	Gene symbol	SPPL2A
	Ensembl ID	ENSG00000138600
	Entrez ID	84888
	Gene name	signal peptide peptidase like 2A
	Synonyms	IMP3\|PSL2
	Gene type	protein_coding
	UniProtAcc	Q8TCT8

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Dataset with differentially expressed gene: SPPL2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.250029	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.337913	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.261107	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.409159	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.281386	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.645323	0.00e+00

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Expression of SPPL2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPPL2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPPL2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPPL2A	hsa-miR-4307	97.1355	NM_032802
SPPL2A	hsa-miR-3143	95.1902	NM_032802
SPPL2A	hsa-miR-548e-5p	93.6839	NM_032802
SPPL2A	hsa-miR-124-3p	91.2537	NM_032802
SPPL2A	hsa-miR-506-3p	91.2537	NM_032802
SPPL2A	hsa-miR-302b-5p	91.2484	NM_032802
SPPL2A	hsa-miR-302d-5p	91.2484	NM_032802
SPPL2A	hsa-miR-5582-5p	91.1281	NM_032802
SPPL2A	hsa-miR-3674	90.7761	NM_032802
SPPL2A	hsa-miR-4267	90.197	NM_032802
SPPL2A	hsa-miR-605-3p	85.8796	NM_032802
SPPL2A	hsa-miR-12136	84.9803	NM_032802
SPPL2A	hsa-miR-302c-5p	82.3984	NM_032802
SPPL2A	hsa-miR-548c-3p	81.1562	NM_032802
SPPL2A	hsa-miR-1183	81.1208	NM_032802

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Motifs and transcription factors (TFs) regulating SPPL2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPPL2A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SPPL2A	transfac_pro__M07397	ZNF148 (directAnnotation).
SPPL2A	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SPPL2A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SPPL2A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
SPPL2A	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SPPL2A	transfac_pro__M02090	E2F4 (directAnnotation).
SPPL2A	transfac_pro__M01714	KLF15 (directAnnotation).
SPPL2A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SPPL2A	jaspar__MA1122.1	TFDP1 (directAnnotation).
SPPL2A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
SPPL2A	transfac_pro__M02281	SP1 (directAnnotation).
SPPL2A	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SPPL2A	transfac_pro__M02898	SMAD3 (directAnnotation).
SPPL2A	metacluster_135.11	NR2C2 (directAnnotation).
SPPL2A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SPPL2A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SPPL2A	cisbp__M00968	MTF2 (directAnnotation).
SPPL2A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SPPL2A	cisbp__M00341	PAX6 (directAnnotation).
SPPL2A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SPPL2A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SPPL2A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SPPL2A	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SPPL2A	transfac_pro__M02913	SP140 (inferredBy_Orthology).
SPPL2A	metacluster_191.5	SPDEF (inferredBy_Orthology).
SPPL2A	transfac_pro__M00430	E2F1 (directAnnotation).
SPPL2A	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SPPL2A	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
SPPL2A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SPPL2A	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
SPPL2A	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
SPPL2A	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
SPPL2A	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
SPPL2A	metacluster_182.10	ZFX (directAnnotation).
SPPL2A	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
SPPL2A	hdpi__ELF2	ELF2 (directAnnotation).
SPPL2A	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
SPPL2A	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
SPPL2A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SPPL2A	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SPPL2A	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
SPPL2A	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
SPPL2A	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
SPPL2A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SPPL2A	transfac_public__M00491	PATZ1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."