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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPOP

Summary for SPOP

Gene information	Gene symbol	SPOP
	Ensembl ID	ENSG00000121067
	Entrez ID	8405
	Gene name	speckle type BTB/POZ protein
	Synonyms	BTBD32\|TEF2
	Gene type	protein_coding
	UniProtAcc	O43791

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Dataset with differentially expressed gene: SPOP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.645308	4.04e-07
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.309168	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.292699	1.36e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.365286	0.00e+00

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Expression of SPOP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPOP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPOP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPOP	hsa-miR-4755-5p	98.719	NM_001007226
SPOP	hsa-miR-5006-3p	98.719	NM_001007226
SPOP	hsa-miR-4446-5p	97.277	NM_001007226
SPOP	hsa-miR-4768-5p	95.0542	NM_001007229
SPOP	hsa-miR-6833-3p	94.6719	NM_001007229
SPOP	hsa-miR-6873-3p	93.3754	NM_001007229
SPOP	hsa-miR-211-5p	93.1243	NM_001007229
SPOP	hsa-miR-204-5p	93.1243	NM_001007229
SPOP	hsa-miR-512-3p	92.7463	NM_001007226
SPOP	hsa-miR-323a-5p	92.4991	NM_001007226
SPOP	hsa-miR-302c-3p	92.021	NM_001007226
SPOP	hsa-miR-302a-3p	92.021	NM_001007226
SPOP	hsa-miR-302b-3p	92.021	NM_001007226
SPOP	hsa-miR-302d-3p	92.021	NM_001007226
SPOP	hsa-miR-302e	92.021	NM_001007226
SPOP	hsa-miR-5706	91.3575	NM_001007229
SPOP	hsa-miR-4782-5p	91.3575	NM_001007229
SPOP	hsa-miR-4719	90.8398	NM_001007226
SPOP	hsa-miR-3692-3p	90.4443	NM_001007226
SPOP	hsa-miR-3919	90.356	NM_001007229
SPOP	hsa-miR-372-3p	89.772	NM_001007226
SPOP	hsa-miR-373-3p	89.772	NM_001007226
SPOP	hsa-miR-520e-3p	89.772	NM_001007226
SPOP	hsa-miR-520d-3p	89.772	NM_001007226
SPOP	hsa-miR-520a-3p	89.772	NM_001007226
SPOP	hsa-miR-520c-3p	89.772	NM_001007226
SPOP	hsa-miR-520b-3p	89.772	NM_001007226
SPOP	hsa-miR-4473	89.2686	NM_001007226
SPOP	hsa-miR-1299	88.7328	NM_001007229
SPOP	hsa-miR-335-3p	88.0527	NM_001007229
SPOP	hsa-miR-767-3p	87.7702	NM_001007226
SPOP	hsa-miR-3163	87.4927	NM_001007226
SPOP	hsa-miR-4755-3p	87.2878	NM_001007226
SPOP	hsa-miR-520f-3p	86.6069	NM_001007226
SPOP	hsa-miR-876-3p	86.5702	NM_001007226
SPOP	hsa-miR-1305	86.5542	NM_001007229
SPOP	hsa-miR-4282	85.9377	NM_001007226
SPOP	hsa-miR-8068	85.704	NM_001007229
SPOP	hsa-miR-4673	85.1401	NM_001007226
SPOP	hsa-miR-875-3p	85.0336	NM_001007226
SPOP	hsa-miR-6739-3p	84.2875	NM_001007229
SPOP	hsa-miR-4645-5p	83.2916	NM_001007226
SPOP	hsa-miR-122b-5p	83.0132	NM_001007226
SPOP	hsa-miR-548aw	82.7774	NM_001007226
SPOP	hsa-miR-331-3p	81.5998	NM_001007229
SPOP	hsa-miR-6823-5p	81.3066	NM_001007226
SPOP	hsa-miR-5088-3p	81.0378	NM_001007229
SPOP	hsa-miR-944	80.7956	NM_001007229

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Motifs and transcription factors (TFs) regulating SPOP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPOP	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SPOP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SPOP	transfac_pro__M07397	ZNF148 (directAnnotation).
SPOP	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
SPOP	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
SPOP	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SPOP	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
SPOP	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
SPOP	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
SPOP	transfac_pro__M01175	ZBTB7B (directAnnotation).
SPOP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SPOP	tfdimers__MD00151	CHURC1 (directAnnotation).
SPOP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SPOP	transfac_pro__M01714	KLF15 (directAnnotation).
SPOP	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SPOP	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
SPOP	transfac_pro__M02089	E2F3 (directAnnotation).
SPOP	metacluster_3.14	WT1; WT1 (directAnnotation).
SPOP	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
SPOP	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SPOP	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
SPOP	transfac_pro__M07436	WT1 (directAnnotation).
SPOP	transfac_pro__M02281	SP1 (directAnnotation).
SPOP	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SPOP	transfac_pro__M02898	SMAD3 (directAnnotation).
SPOP	transfac_public__M00491	PATZ1 (directAnnotation).
SPOP	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SPOP	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SPOP	transfac_pro__M04617	ZBTB7A (directAnnotation).
SPOP	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SPOP	transfac_pro__M07387	ZBTB7A (directAnnotation).
SPOP	transfac_pro__M00716	ZBTB14 (directAnnotation).
SPOP	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SPOP	hdpi__HIP2	UBE2K (directAnnotation).
SPOP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SPOP	transfac_pro__M03876	ZBTB33 (directAnnotation).
SPOP	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SPOP	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SPOP	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SPOP	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SPOP	transfac_pro__M04950	EGR1 (directAnnotation).
SPOP	transfac_pro__M00652	NRF1 (directAnnotation).
SPOP	metacluster_55.5	ZNF541 (directAnnotation).
SPOP	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
SPOP	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
SPOP	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
SPOP	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
SPOP	transfac_pro__M06032	ZNF727 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."