Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPOCK2

Summary for SPOCK2

Gene information	Gene symbol	SPOCK2
	Ensembl ID	ENSG00000107742
	Entrez ID	9806
	Gene name	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
	Synonyms	KIAA0275\|testican-2
	Gene type	protein_coding
	UniProtAcc	Q92563

Top

Dataset with differentially expressed gene: SPOCK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.269358	5.43e-30
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.274568	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.276147	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.275431	4.13e-25
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.33736	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.312545	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.513627	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.470617	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.268578	6.77e-17
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.308343	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.372102	4.36e-10
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.342211	7.55e-05
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.353588	2.86e-22
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.398161	7.51e-08
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.418274	2.10e-44
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	-0.399842	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.632374	4.13e-12

Top

Expression of SPOCK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SPOCK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SPOCK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPOCK2	hsa-miR-8485	98.2017	NM_014767
SPOCK2	hsa-miR-4492	96.5097	NM_001244950
SPOCK2	hsa-miR-6825-5p	92.7244	NM_001134434
SPOCK2	hsa-miR-4291	91.5089	NM_001244950
SPOCK2	hsa-miR-940	91.4681	NM_001244950
SPOCK2	hsa-miR-6808-5p	91.4681	NM_001244950
SPOCK2	hsa-miR-6893-5p	91.4681	NM_001244950
SPOCK2	hsa-miR-6728-3p	89.9054	NM_001244950
SPOCK2	hsa-miR-3928-5p	89.44	NM_014767
SPOCK2	hsa-miR-6806-3p	89.44	NM_014767
SPOCK2	hsa-miR-3150a-3p	89.3051	NM_001134434
SPOCK2	hsa-miR-6763-5p	89.3051	NM_001134434
SPOCK2	hsa-miR-1197	89.0746	NM_001244950
SPOCK2	hsa-miR-4498	88.983	NM_001244950
SPOCK2	hsa-miR-6867-5p	88.2469	NM_014767
SPOCK2	hsa-miR-762	87.0464	NM_001244950
SPOCK2	hsa-miR-5001-5p	87.017	NM_001244950
SPOCK2	hsa-miR-6511a-5p	86.2484	NM_001244950
SPOCK2	hsa-miR-1910-3p	86.0897	NM_001244950
SPOCK2	hsa-miR-4441	84.1765	NM_014767
SPOCK2	hsa-miR-340-5p	83.1477	NM_001244950
SPOCK2	hsa-miR-4478	82.0175	NM_014767
SPOCK2	hsa-miR-6079	81.9277	NM_001134434
SPOCK2	hsa-miR-486-3p	81.7536	NM_014767
SPOCK2	hsa-miR-4685-5p	81.6445	NM_001244950
SPOCK2	hsa-miR-6837-5p	81.6445	NM_001244950
SPOCK2	hsa-miR-4430	81.2184	NM_014767
SPOCK2	hsa-miR-3652	81.2184	NM_014767
SPOCK2	hsa-miR-4270	80.3804	NM_014767

Page: 1

Top

Motifs and transcription factors (TFs) regulating SPOCK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPOCK2	transfac_pro__M06406	ZNF534 (directAnnotation).
SPOCK2	transfac_pro__M06519	ZNF397 (directAnnotation).
SPOCK2	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
SPOCK2	cisbp__M00212	SOX13 (inferredBy_Orthology).
SPOCK2	transfac_pro__M06750	ZNF510 (directAnnotation).
SPOCK2	swissregulon__hs__FOXO3	FOXO3 (directAnnotation).
SPOCK2	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
SPOCK2	metacluster_130.12	ZNF182; ZNF35; ZNF674; ZNF677; ZNF79; ZNF836 (directAnnotation).
SPOCK2	taipale_tf_pairs__TEAD4_HOXA2_RCATTCNNNNNNCATTA_CAP	HOXA2; TEAD4 (directAnnotation).
SPOCK2	taipale_tf_pairs__FOXA1_TRNGTAAACA_HT	FOXA1 (directAnnotation).
SPOCK2	transfac_pro__M05626	ZNF780A (directAnnotation).
SPOCK2	metacluster_147.6	MGA; TBX1; TBX1; TBX1; TBX15; TBX19; TBX19; TBX20; TBX20; TBX21; TBX6; TBXT; TBXT; TBXT; TBXT; TBXT (directAnnotation). TBX18; TBX6 (inferredBy_Orthology).
SPOCK2	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).
SPOCK2	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
SPOCK2	transfac_pro__M06839	ZNF263 (inferredBy_Orthology).
SPOCK2	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
SPOCK2	transfac_pro__M06557	ZNF418 (directAnnotation).
SPOCK2	transfac_pro__M06508	ZNF114 (directAnnotation).
SPOCK2	metacluster_84.18	RARA (directAnnotation).
SPOCK2	transfac_pro__M06042	ZNF208 (directAnnotation).
SPOCK2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SPOCK2	transfac_pro__M06364	ZNF841 (directAnnotation).
SPOCK2	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
SPOCK2	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
SPOCK2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
SPOCK2	tfdimers__MD00425	ELF5; SMAD4 (directAnnotation).
SPOCK2	transfac_pro__M06185	ZNF92 (directAnnotation).
SPOCK2	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
SPOCK2	transfac_pro__M06340	ZNF790 (directAnnotation).
SPOCK2	taipale_tf_pairs__HOXB2_RFX5_TAATKRNNNNGCAAC_CAP_repr	HOXB2; RFX5 (directAnnotation).
SPOCK2	metacluster_161.33	DLX5 (directAnnotation).
SPOCK2	transfac_pro__M05765	ZNF684 (directAnnotation).
SPOCK2	hdpi__PRRX1	PRRX1 (directAnnotation).
SPOCK2	taipale_tf_pairs__GCM1_FOXI1_RTMAACATRNGGGN_CAP_repr	FOXI1; GCM1 (directAnnotation).
SPOCK2	taipale_cyt_meth__FOXO3_NTCCCCACACN_eDBD	FOXO3 (directAnnotation).
SPOCK2	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
SPOCK2	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
SPOCK2	transfac_pro__M06391	ZNF836 (directAnnotation).
SPOCK2	transfac_pro__M05942	ZNF700 (directAnnotation).
SPOCK2	tfdimers__MD00423	ARID3A; PAX4 (directAnnotation).
SPOCK2	kznf__ZNF3_Imbeault2017_RP_RCADE	ZNF3 (directAnnotation).
SPOCK2	transfac_public__M00039	CREB1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."