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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPIN1

Summary for SPIN1

Gene information	Gene symbol	SPIN1
	Ensembl ID	ENSG00000106723
	Entrez ID	10927
	Gene name	spindlin 1
	Synonyms	SPIN\|TDRD24
	Gene type	protein_coding
	UniProtAcc	Q9Y657

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Dataset with differentially expressed gene: SPIN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.285998	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.284666	2.46e-15
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.266385	5.78e-11

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Expression of SPIN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPIN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SPIN1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SPIN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPIN1	hsa-miR-96-5p	99.8574	NM_006717
SPIN1	hsa-miR-12133	99.7719	NM_006717
SPIN1	hsa-miR-1271-5p	99.7719	NM_006717
SPIN1	hsa-miR-3618	99.6903	NM_006717
SPIN1	hsa-miR-3163	99.6869	NM_006717
SPIN1	hsa-miR-6867-5p	98.9689	NM_006717
SPIN1	hsa-miR-182-5p	98.6366	NM_006717
SPIN1	hsa-miR-570-3p	98.5766	NM_006717
SPIN1	hsa-miR-934	98.4896	NM_006717
SPIN1	hsa-miR-7856-5p	98.4494	NM_006717
SPIN1	hsa-miR-3613-3p	98.2042	NM_006717
SPIN1	hsa-miR-8485	97.6164	NM_006717
SPIN1	hsa-miR-625-5p	97.4486	NM_006717
SPIN1	hsa-miR-548aw	97.2428	NM_006717
SPIN1	hsa-miR-590-3p	95.3564	NM_006717
SPIN1	hsa-miR-548an	94.8633	NM_006717
SPIN1	hsa-miR-4477b	94.3436	NM_006717
SPIN1	hsa-miR-935	94.2287	NM_006717
SPIN1	hsa-miR-497-3p	93.9954	NM_006717
SPIN1	hsa-miR-33a-3p	92.9077	NM_006717
SPIN1	hsa-miR-3692-3p	92.89	NM_006717
SPIN1	hsa-miR-29b-1-5p	92.8288	NM_006717
SPIN1	hsa-miR-548d-3p	92.561	NM_006717
SPIN1	hsa-miR-548bb-3p	92.561	NM_006717
SPIN1	hsa-miR-548h-3p	92.561	NM_006717
SPIN1	hsa-miR-548z	92.561	NM_006717
SPIN1	hsa-miR-548ac	92.561	NM_006717
SPIN1	hsa-miR-12131	91.3552	NM_006717
SPIN1	hsa-miR-1283	91.0146	NM_006717
SPIN1	hsa-miR-4793-3p	90.901	NM_006717
SPIN1	hsa-miR-1276	90.4564	NM_006717
SPIN1	hsa-miR-1825	89.9599	NM_006717
SPIN1	hsa-miR-4327	89.8774	NM_006717
SPIN1	hsa-miR-1252-3p	89.3611	NM_006717
SPIN1	hsa-miR-4307	88.8091	NM_006717
SPIN1	hsa-miR-5009-5p	88.7577	NM_006717
SPIN1	hsa-miR-4527	88.4526	NM_006717
SPIN1	hsa-miR-5589-3p	88.3695	NM_006717
SPIN1	hsa-miR-10527-5p	88.1394	NM_006717
SPIN1	hsa-miR-3682-5p	87.9858	NM_006717
SPIN1	hsa-miR-548c-3p	87.1239	NM_006717
SPIN1	hsa-miR-6503-5p	86.7541	NM_006717
SPIN1	hsa-miR-8058	86.6947	NM_006717
SPIN1	hsa-miR-3941	86.6895	NM_006717
SPIN1	hsa-miR-3978	86.5144	NM_006717
SPIN1	hsa-miR-100-3p	86.5016	NM_006717
SPIN1	hsa-miR-7-1-3p	86.4431	NM_006717
SPIN1	hsa-miR-7-2-3p	86.4431	NM_006717
SPIN1	hsa-miR-374a-5p	86.3696	NM_006717
SPIN1	hsa-miR-124-5p	86.1908	NM_006717

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Motifs and transcription factors (TFs) regulating SPIN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPIN1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SPIN1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SPIN1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SPIN1	transfac_pro__M04866	HDAC2 (directAnnotation).
SPIN1	jaspar__MA1122.1	TFDP1 (directAnnotation).
SPIN1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SPIN1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SPIN1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SPIN1	metacluster_7.13	ZFX (directAnnotation).
SPIN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SPIN1	cisbp__M00968	MTF2 (directAnnotation).
SPIN1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SPIN1	cisbp__M00341	PAX6 (directAnnotation).
SPIN1	metacluster_198.3	ZFP64 (directAnnotation).
SPIN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SPIN1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SPIN1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SPIN1	cisbp__M00788	ZFY (inferredBy_Orthology).
SPIN1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SPIN1	metacluster_175.1	ZNF283 (directAnnotation).
SPIN1	hdpi__ZNF304	ZNF304 (directAnnotation).
SPIN1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SPIN1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SPIN1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SPIN1	transfac_pro__M01199	TRIM28 (directAnnotation).
SPIN1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SPIN1	metacluster_151.2	ZNF23 (directAnnotation).
SPIN1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SPIN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SPIN1	transfac_pro__M03806	ZBTB7C (directAnnotation).
SPIN1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SPIN1	jaspar__MA0079.5	SP1 (directAnnotation).
SPIN1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
SPIN1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
SPIN1	transfac_pro__M01253	CNOT3 (directAnnotation).
SPIN1	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
SPIN1	transfac_pro__M04817	ZBTB33 (directAnnotation).
SPIN1	transfac_pro__M05712	ZNF134 (directAnnotation).
SPIN1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."