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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: SPI1

Summary for SPI1

Gene information	Gene symbol	SPI1
	Ensembl ID	ENSG00000066336
	Entrez ID	6688
	Gene name	Spi-1 proto-oncogene
	Synonyms	OF\|PU.1\|SFPI1\|SPI-1\|SPI-A
	Gene type	protein_coding
	UniProtAcc	P17947

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Dataset with differentially expressed gene: SPI1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.407328	4.34e-10
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.462903	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.37958	5.21e-05
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.342836	1.21e-10
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.289524	6.43e-24
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.614827	2.90e-26
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.26454	9.11e-06
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-1.43445	9.57e-04
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.355431	5.11e-07
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.418834	1.22e-22
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	Erythrocytes	0.409521	2.65e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.31111	3.82e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.626226	0.00e+00

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Expression of SPI1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPI1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPI1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPI1	hsa-miR-4728-5p	87.4857	NM_003120
SPI1	hsa-miR-887-5p	83.2761	NM_003120
SPI1	hsa-miR-6785-5p	81.646	NM_003120
SPI1	hsa-miR-6780a-5p	80.745	NM_003120

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Motifs and transcription factors (TFs) regulating SPI1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPI1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
SPI1	tfdimers__MD00222	ASCL1; BHLHE40; BHLHE41; GATA1; GATA2; GATA3; GATA4; GATA5; GATA6; HAND1; HAND2; MAX; MITF; MXD1; MXD3; MXD4; MXI1; MYC; MYCN; MYF5; MYF6; MYOD1; MYOG; NHLH1; TAL1; TAL2; TCF12; TCF3; TCF4; TFE3; TFEB; USF1; USF2 (directAnnotation).
SPI1	transfac_pro__M06692	PRDM10 (directAnnotation).
SPI1	transfac_pro__M05935	ZNF382 (directAnnotation).
SPI1	swissregulon__hs__HBP1	HBP1 (directAnnotation).
SPI1	metacluster_113.5	OVOL1; OVOL1; OVOL2; OVOL2; OVOL2; OVOL2 (directAnnotation). OVOL1; OVOL1; OVOL1 (inferredBy_Orthology).
SPI1	tfdimers__MD00039	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
SPI1	metacluster_145.10	ZNF24 (directAnnotation).
SPI1	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
SPI1	transfac_pro__M04706	RELA (directAnnotation).
SPI1	hdpi__FOSL1	FOSL1 (directAnnotation).
SPI1	metacluster_156.4	NFIL3 (directAnnotation). NFIL3 (inferredBy_Orthology).
SPI1	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
SPI1	tfdimers__MD00404	FOXA1; FOXA2; FOXA3; FOXP3 (directAnnotation).
SPI1	cisbp__M01815	CEBPE (inferredBy_Orthology).
SPI1	metacluster_46.5	HLF; TEF (directAnnotation).
SPI1	jaspar__MA1954.1	FOXO1 (directAnnotation).
SPI1	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).
SPI1	transfac_pro__M05560	AEBP2 (directAnnotation).
SPI1	metacluster_59.1	HOXA9; HOXA9; HOXA9; HOXB6; HOXB7; HOXB7; HOXB8; HOXB8; HOXC6; HOXC8; HOXC8; MEIS1; MEIS1; MEIS2; MEIS2; PBX1; PBX1; PBX1; PBX2; PBX2 (directAnnotation). HOXA9; HOXA9; HOXB4; HOXB6; HOXC6; HOXC9; HOXC9; LEF1; PDX1; PDX1; TCF7L2 (inferredBy_Orthology).
SPI1	taipale_tf_pairs__TEAD4_SPDEF_RGWATSCGGATGNNNNTCCKNNN_CAP_repr	SPDEF; TEAD4 (directAnnotation).
SPI1	jaspar__MA1508.1	IKZF1 (directAnnotation).
SPI1	tfdimers__MD00554	CUX1; EP300 (directAnnotation).
SPI1	metacluster_82.5	ZKSCAN8; ZNF205; ZNF227; ZNF594 (directAnnotation).
SPI1	taipale_tf_pairs__PBX4_HOXA10_YNNRTAAATCAATCA_CAP_repr	HOXA10; PBX4 (directAnnotation).
SPI1	hocomoco__CUX2_HUMAN.H11MO.0.D	CUX2 (directAnnotation).
SPI1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
SPI1	metacluster_95.1	ZNF274; ZNF574; ZNF574 (directAnnotation).
SPI1	transfac_pro__M06249	ZNF616 (directAnnotation).
SPI1	transfac_pro__M05829	ZNF627 (directAnnotation).
SPI1	transfac_pro__M06487	ZNF695 (directAnnotation).
SPI1	jaspar__MA1956.1	FOXO1 (directAnnotation).
SPI1	jaspar__MA1946.1	FOXI1 (directAnnotation).
SPI1	tfdimers__MD00221	FOXG1; FOXO1; GABPA (directAnnotation).
SPI1	jaspar__MA1955.1	FOXO1 (directAnnotation).
SPI1	kznf__ZNF3_Imbeault2017_RP_RCADE	ZNF3 (directAnnotation).
SPI1	metacluster_46.2	CEBPA; DDIT3; DDIT3 (directAnnotation).
SPI1	metacluster_174.4	PBX1; PBX1; PBX1; PBX1 (directAnnotation).
SPI1	transfac_pro__M06962	HES7 (inferredBy_Orthology).
SPI1	metacluster_167.8	ZKSCAN5; ZKSCAN5 (directAnnotation).
SPI1	metacluster_57.5	ZKSCAN5 (directAnnotation).
SPI1	kznf__GLI4_Schmitges2016_ChIP-seq	GLI4 (directAnnotation).
SPI1	metacluster_64.15	NR1H4; NR1H4; NR1I2; NR1I3; RXRA (directAnnotation). NR1H3 (inferredBy_Orthology).
SPI1	metacluster_27.21	CNOT6; ZNF112 (directAnnotation). ZNF112 (inferredBy_Orthology).
SPI1	transfac_pro__M05825	ZNF572 (directAnnotation).
SPI1	kznf__ZNF77_Imbeault2017_RP_ChIP-seq	ZNF77 (directAnnotation).
SPI1	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
SPI1	jaspar__MA1936.1	FOXO1 (inferredBy_Orthology).
SPI1	hocomoco__NKX61_MOUSE.H11MO.1.A	NKX6-1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
SPI1	transfac_pro__M04722	up	cDCs	GSE169246_PacAteBlood	pre
SPI1	metacluster_167.5	up	cDCs	GSE169246_PacBlood	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."