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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPATA5

Summary for SPATA5

Gene information	Gene symbol	SPATA5
	Ensembl ID	ENSG00000145375
	Entrez ID	166378
	Gene name	spermatogenesis associated 5
	Synonyms	AFG2\|SPAF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SPATA5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.36	9.13e-03

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Expression of SPATA5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPATA5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPATA5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPATA5	hsa-miR-373-5p	99.1003	NM_145207
SPATA5	hsa-miR-371b-5p	99.1003	NM_145207
SPATA5	hsa-miR-616-5p	99.1003	NM_145207
SPATA5	hsa-miR-4282	98.5807	NM_145207
SPATA5	hsa-miR-3613-3p	98.4007	NM_145207
SPATA5	hsa-miR-1299	93.9376	NM_145207
SPATA5	hsa-miR-4639-3p	92.303	NM_145207
SPATA5	hsa-miR-4297	92.0443	NM_145207
SPATA5	hsa-miR-544b	91.877	NM_145207
SPATA5	hsa-miR-548ar-3p	89.1824	NM_145207
SPATA5	hsa-miR-548a-3p	87.4508	NM_145207
SPATA5	hsa-miR-548bc	87.1807	NM_145207
SPATA5	hsa-miR-548az-3p	87.1807	NM_145207
SPATA5	hsa-miR-548f-3p	87.1807	NM_145207
SPATA5	hsa-miR-548e-3p	87.1807	NM_145207
SPATA5	hsa-miR-627-3p	86.3825	NM_145207
SPATA5	hsa-miR-5581-5p	86.0194	NM_145207
SPATA5	hsa-miR-5007-3p	85.8382	NM_145207
SPATA5	hsa-miR-875-3p	85.4842	NM_145207
SPATA5	hsa-miR-518c-5p	85.32	NM_145207
SPATA5	hsa-miR-3059-5p	84.4894	NM_145207
SPATA5	hsa-miR-6881-3p	84.056	NM_145207
SPATA5	hsa-miR-656-3p	83.3987	NM_145207
SPATA5	hsa-miR-3191-5p	83.3437	NM_145207
SPATA5	hsa-miR-196a-1-3p	83.0807	NM_145207
SPATA5	hsa-miR-4307	82.4111	NM_145207
SPATA5	hsa-miR-548c-3p	82.2276	NM_145207
SPATA5	hsa-miR-590-3p	82.1146	NM_145207
SPATA5	hsa-miR-3187-3p	82.0844	NM_145207
SPATA5	hsa-miR-1185-5p	81.4276	NM_145207
SPATA5	hsa-miR-4314	81.1171	NM_145207
SPATA5	hsa-miR-3924	80.9334	NM_145207
SPATA5	hsa-miR-7158-3p	80.7193	NM_145207

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Motifs and transcription factors (TFs) regulating SPATA5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."