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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPAST

Summary for SPAST

Gene information	Gene symbol	SPAST
	Ensembl ID	ENSG00000021574
	Entrez ID	6683
	Gene name	spastin
	Synonyms	ADPSP\|FSP2\|KIAA1083\|SPG4
	Gene type	protein_coding
	UniProtAcc	Q9UBP0

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Dataset with differentially expressed gene: SPAST

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.321425	2.87e-20

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Expression of SPAST in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPAST

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPAST

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPAST	hsa-miR-6740-3p	97.7007	NM_014946
SPAST	hsa-miR-3658	97.1059	NM_199436
SPAST	hsa-miR-4503	95.9597	NM_014946
SPAST	hsa-miR-3124-3p	95.7689	NM_199436
SPAST	hsa-miR-96-5p	95.6217	NM_014946
SPAST	hsa-miR-6881-3p	95.4041	NM_199436
SPAST	hsa-miR-3059-5p	95.3646	NM_199436
SPAST	hsa-miR-126-5p	95.0703	NM_199436
SPAST	hsa-miR-12133	94.4923	NM_014946
SPAST	hsa-miR-1271-5p	94.4923	NM_014946
SPAST	hsa-miR-8064	93.7556	NM_014946
SPAST	hsa-miR-30a-5p	93.1829	NM_014946
SPAST	hsa-miR-30b-5p	93.1829	NM_014946
SPAST	hsa-miR-30d-5p	93.1829	NM_014946
SPAST	hsa-miR-30c-5p	93.1829	NM_014946
SPAST	hsa-miR-30e-5p	93.1829	NM_014946
SPAST	hsa-miR-498-3p	91.706	NM_014946
SPAST	hsa-miR-4729	91.4055	NM_014946
SPAST	hsa-miR-323b-3p	91.0649	NM_199436
SPAST	hsa-miR-4795-3p	90.9468	NM_199436
SPAST	hsa-miR-1205	90.6859	NM_014946
SPAST	hsa-miR-10394-5p	90.6859	NM_014946
SPAST	hsa-miR-6864-5p	90.6089	NM_199436
SPAST	hsa-miR-548ad-3p	90.4444	NM_199436
SPAST	hsa-miR-944	90.1519	NM_199436
SPAST	hsa-miR-153-5p	90.1376	NM_199436
SPAST	hsa-let-7f-1-3p	88.2754	NM_199436
SPAST	hsa-let-7a-3p	88.2754	NM_199436
SPAST	hsa-let-7b-3p	88.2754	NM_199436
SPAST	hsa-miR-98-3p	88.2754	NM_199436
SPAST	hsa-miR-2681-5p	87.8391	NM_199436
SPAST	hsa-miR-186-5p	87.526	NM_014946
SPAST	hsa-miR-182-5p	87.2973	NM_014946
SPAST	hsa-let-7c-3p	87.0953	NM_199436
SPAST	hsa-miR-5088-3p	84.576	NM_199436
SPAST	hsa-miR-568	84.4827	NM_014946
SPAST	hsa-miR-5688	84.3296	NM_014946
SPAST	hsa-miR-495-3p	84.3296	NM_014946
SPAST	hsa-miR-936	84.1487	NM_199436
SPAST	hsa-miR-3065-5p	83.3551	NM_199436
SPAST	hsa-miR-769-5p	82.0185	NM_199436
SPAST	hsa-miR-3074-3p	81.8845	NM_199436
SPAST	hsa-miR-371b-5p	81.8528	NM_199436
SPAST	hsa-miR-373-5p	81.8528	NM_199436
SPAST	hsa-miR-616-5p	81.8528	NM_199436
SPAST	hsa-miR-11400	81.4342	NM_199436
SPAST	hsa-miR-380-3p	81.3729	NM_199436
SPAST	hsa-miR-338-5p	81.1713	NM_199436
SPAST	hsa-miR-384	80.8512	NM_014946
SPAST	hsa-miR-3686	80.7371	NM_014946

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Motifs and transcription factors (TFs) regulating SPAST

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPAST	metacluster_141.4	GLIS2 (directAnnotation).
SPAST	transfac_pro__M04950	EGR1 (directAnnotation).
SPAST	transfac_pro__M02012	HIF1A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."