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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPAG1

Summary for SPAG1

Gene information	Gene symbol	SPAG1
	Ensembl ID	ENSG00000104450
	Entrez ID	6674
	Gene name	sperm associated antigen 1
	Synonyms	CILD28\|CT140\|DNAAF13\|FLJ32920\|HSD-3.8\|SP75\|TPIS
	Gene type	protein_coding
	UniProtAcc	Q07617

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Dataset with differentially expressed gene: SPAG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.563565	0.00e+00

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Expression of SPAG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPAG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPAG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPAG1	hsa-miR-8065	95.4556	NM_003114
SPAG1	hsa-miR-6885-3p	94.6807	NM_003114
SPAG1	hsa-miR-628-3p	92.8679	NM_003114
SPAG1	hsa-miR-891b	88.4573	NM_003114
SPAG1	hsa-miR-2116-5p	87.151	NM_003114
SPAG1	hsa-miR-4677-5p	85.1887	NM_003114
SPAG1	hsa-miR-4699-3p	84.6493	NM_003114
SPAG1	hsa-miR-7705	84.552	NM_003114
SPAG1	hsa-miR-12124	84.4254	NM_003114
SPAG1	hsa-miR-4496	84.4254	NM_003114
SPAG1	hsa-miR-33a-3p	83.1824	NM_003114
SPAG1	hsa-miR-4802-5p	82.7249	NM_003114
SPAG1	hsa-miR-1843	82.7249	NM_003114
SPAG1	hsa-miR-4650-3p	81.5387	NM_003114
SPAG1	hsa-miR-5692a	81.4773	NM_003114
SPAG1	hsa-miR-4799-5p	80.9315	NM_003114

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Motifs and transcription factors (TFs) regulating SPAG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPAG1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SPAG1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SPAG1	metacluster_7.13	ZFX (directAnnotation).
SPAG1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SPAG1	cisbp__M00968	MTF2 (directAnnotation).
SPAG1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SPAG1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SPAG1	cisbp__M00341	PAX6 (directAnnotation).
SPAG1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SPAG1	cisbp__M00788	ZFY (inferredBy_Orthology).
SPAG1	metacluster_175.1	ZNF283 (directAnnotation).
SPAG1	hdpi__ZNF304	ZNF304 (directAnnotation).
SPAG1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SPAG1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SPAG1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SPAG1	transfac_pro__M01199	TRIM28 (directAnnotation).
SPAG1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SPAG1	metacluster_151.2	ZNF23 (directAnnotation).
SPAG1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SPAG1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SPAG1	transfac_pro__M03806	ZBTB7C (directAnnotation).
SPAG1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."