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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SP100

Summary for SP100

Gene information	Gene symbol	SP100
	Ensembl ID	ENSG00000067066
	Entrez ID	6672
	Gene name	SP100 nuclear antigen
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P23497

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Dataset with differentially expressed gene: SP100

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.75608	3.76e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.346545	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.269875	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.353795	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.360487	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.397627	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.296075	1.25e-07
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.322612	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.996197	5.85e-05
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.306711	2.21e-17
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.278679	3.23e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.262545	1.12e-08
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.636438	0.00e+00

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Expression of SP100 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SP100

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SP100

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SP100	hsa-miR-1911-3p	93.9442	NM_003113
SP100	hsa-miR-4743-3p	92.8761	NM_001206704
SP100	hsa-miR-5571-5p	92.7767	NM_001080391
SP100	hsa-miR-6888-3p	92.605	NM_001206704
SP100	hsa-miR-4777-5p	92.3953	NM_001080391
SP100	hsa-miR-4693-3p	92.2454	NM_001206704
SP100	hsa-miR-146a-3p	91.6618	NM_001080391
SP100	hsa-miR-5590-5p	91.0415	NM_003113
SP100	hsa-miR-4796-5p	90.6827	NM_001206704
SP100	hsa-miR-4652-3p	89.5716	NM_001206704
SP100	hsa-miR-580-3p	89.4	NM_001080391
SP100	hsa-miR-629-3p	88.7074	NM_001080391
SP100	hsa-miR-766-5p	88.4225	NM_003113
SP100	hsa-miR-511-5p	88.1031	NM_001080391
SP100	hsa-miR-12131	87.9851	NM_001080391
SP100	hsa-miR-3529-3p	87.7287	NM_001206704
SP100	hsa-miR-642b-5p	86.9002	NM_001080391
SP100	hsa-miR-3907	86.7835	NM_001206704
SP100	hsa-miR-624-3p	86.4353	NM_001206704
SP100	hsa-miR-3156-5p	84.868	NM_001206704
SP100	hsa-miR-4326	84.6391	NM_001080391
SP100	hsa-miR-6500-5p	84.0361	NM_003113
SP100	hsa-miR-4633-3p	84.0361	NM_003113
SP100	hsa-miR-4774-3p	83.5494	NM_001080391
SP100	hsa-miR-12122	83.4963	NM_001080391
SP100	hsa-miR-551b-5p	83.3374	NM_001206701
SP100	hsa-miR-34c-3p	82.7662	NM_001206704
SP100	hsa-miR-1284	82.7481	NM_003113
SP100	hsa-miR-7161-5p	82.707	NM_001206701
SP100	hsa-miR-510-3p	82.6004	NM_003113
SP100	hsa-miR-548av-3p	82.5835	NM_001080391
SP100	hsa-miR-134-3p	82.4919	NM_001080391
SP100	hsa-miR-4531	82.1084	NM_001080391
SP100	hsa-miR-4776-3p	82.0749	NM_003113
SP100	hsa-miR-19a-3p	81.6017	NM_001080391
SP100	hsa-miR-19b-3p	81.6017	NM_001080391
SP100	hsa-miR-7161-3p	81.1992	NM_001206704
SP100	hsa-miR-6873-3p	80.8853	NM_003113
SP100	hsa-miR-4711-3p	80.8233	NM_001080391
SP100	hsa-miR-548c-3p	80.6219	NM_001206704
SP100	hsa-miR-3923	80.0858	NM_001080391

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Motifs and transcription factors (TFs) regulating SP100

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SP100	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
SP100	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
SP100	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
SP100	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
SP100	metacluster_52.11	ZNF184 (directAnnotation).
SP100	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
SP100	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
SP100	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SP100	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
SP100	cisbp__M02645	ETS1 (directAnnotation).
SP100	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
SP100	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SP100	transfac_pro__M00492	STAT1 (directAnnotation).
SP100	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
SP100	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SP100	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
SP100	transfac_pro__M04887	TCF12 (directAnnotation).
SP100	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
SP100	hdpi__SSBP3	SSBP3 (directAnnotation).
SP100	tfdimers__MD00026	IRF1; MYB (directAnnotation).
SP100	transfac_pro__M04706	RELA (directAnnotation).
SP100	transfac_pro__M06493	ZNF668 (inferredBy_Orthology).
SP100	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
SP100	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
SP100	hdpi__LARP1	LARP1 (directAnnotation).
SP100	metacluster_155.11	SPZ1 (directAnnotation).
SP100	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
SP100	metacluster_167.7	IRF8 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."