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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SOX9

Summary for SOX9

Gene information	Gene symbol	SOX9
	Ensembl ID	ENSG00000125398
	Entrez ID	6662
	Gene name	SRY-box transcription factor 9
	Synonyms	CMD1\|CMPD1\|SRA1
	Gene type	protein_coding
	UniProtAcc	P48436

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Dataset with differentially expressed gene: SOX9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.563114	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.320153	2.13e-22
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.307883	9.52e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.367104	3.11e-30
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.348559	1.42e-28
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-2.1896	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.529182	0.00e+00

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Expression of SOX9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SOX9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SOX9	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SOX9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SOX9	hsa-miR-98-3p	99.9656	NM_000346
SOX9	hsa-let-7b-3p	99.9656	NM_000346
SOX9	hsa-let-7f-1-3p	99.9656	NM_000346
SOX9	hsa-let-7a-3p	99.9656	NM_000346
SOX9	hsa-miR-3185	99.3987	NM_000346
SOX9	hsa-miR-3613-3p	98.5411	NM_000346
SOX9	hsa-miR-4311	98.4738	NM_000346
SOX9	hsa-miR-3148	97.8491	NM_000346
SOX9	hsa-miR-1185-1-3p	97.6114	NM_000346
SOX9	hsa-let-7f-2-3p	97.6114	NM_000346
SOX9	hsa-miR-1185-2-3p	97.6114	NM_000346
SOX9	hsa-miR-7856-5p	96.7374	NM_000346
SOX9	hsa-miR-30d-5p	96.7149	NM_000346
SOX9	hsa-miR-30a-5p	96.7149	NM_000346
SOX9	hsa-miR-30b-5p	96.7149	NM_000346
SOX9	hsa-miR-30c-5p	96.7149	NM_000346
SOX9	hsa-miR-30e-5p	96.7149	NM_000346
SOX9	hsa-miR-5692a	95.6669	NM_000346
SOX9	hsa-miR-6826-3p	94.8377	NM_000346
SOX9	hsa-miR-1277-5p	94.3182	NM_000346
SOX9	hsa-miR-5195-3p	94.1204	NM_000346
SOX9	hsa-miR-6887-3p	94.0634	NM_000346
SOX9	hsa-miR-145-5p	93.581	NM_000346
SOX9	hsa-miR-5011-5p	93.5659	NM_000346
SOX9	hsa-miR-4477b	93.1186	NM_000346
SOX9	hsa-miR-548ar-3p	93.0642	NM_000346
SOX9	hsa-miR-548bc	92.9188	NM_000346
SOX9	hsa-miR-548f-3p	92.9188	NM_000346
SOX9	hsa-miR-548e-3p	92.9188	NM_000346
SOX9	hsa-miR-548az-3p	92.9188	NM_000346
SOX9	hsa-miR-548a-3p	92.8769	NM_000346
SOX9	hsa-miR-511-5p	90.9909	NM_000346
SOX9	hsa-miR-300	90.9803	NM_000346
SOX9	hsa-miR-381-3p	90.9803	NM_000346
SOX9	hsa-miR-3714	90.0388	NM_000346
SOX9	hsa-miR-605-5p	89.3846	NM_000346
SOX9	hsa-miR-599	89.1696	NM_000346
SOX9	hsa-miR-6507-3p	88.7482	NM_000346
SOX9	hsa-miR-548aw	87.9053	NM_000346
SOX9	hsa-miR-4666a-3p	87.6844	NM_000346
SOX9	hsa-miR-8485	86.8878	NM_000346
SOX9	hsa-miR-514a-5p	86.8636	NM_000346
SOX9	hsa-miR-4729	86.7907	NM_000346
SOX9	hsa-miR-588	85.226	NM_000346
SOX9	hsa-miR-6795-3p	85.077	NM_000346
SOX9	hsa-miR-206	85.0008	NM_000346
SOX9	hsa-miR-1-3p	85.0008	NM_000346
SOX9	hsa-miR-613	84.6808	NM_000346
SOX9	hsa-miR-130b-5p	84.6436	NM_000346
SOX9	hsa-miR-101-2-5p	83.8464	NM_000346

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Motifs and transcription factors (TFs) regulating SOX9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SOX9	metacluster_172.23	ZBTB32; ZBTB32 (directAnnotation).
SOX9	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
SOX9	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SOX9	tfdimers__MD00339	HMGA1; HMGA2; TFAP2C (directAnnotation).
SOX9	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
SOX9	transfac_pro__M05770	ZNF77 (directAnnotation).
SOX9	tfdimers__MD00516	SOX10 (directAnnotation).
SOX9	swissregulon__hs__EZH2	EZH2 (directAnnotation).
SOX9	jaspar__MA0079.5	SP1 (directAnnotation).
SOX9	hdpi__NFIX	NFIX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."