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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SOX6

Summary for SOX6

Gene information	Gene symbol	SOX6
	Ensembl ID	ENSG00000110693
	Entrez ID	55553
	Gene name	SRY-box transcription factor 6
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P35712

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Dataset with differentially expressed gene: SOX6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.321713	4.92e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.331562	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.287789	1.16e-02

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Expression of SOX6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SOX6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SOX6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SOX6	hsa-miR-499a-5p	99.9817	NM_001145811
SOX6	hsa-miR-3529-3p	99.9024	NM_001145811
SOX6	hsa-miR-8087	99.9004	NM_001145811
SOX6	hsa-miR-3148	99.7219	NM_001145811
SOX6	hsa-miR-3658	99.4883	NM_001145811
SOX6	hsa-miR-196a-1-3p	99.3396	NM_001145811
SOX6	hsa-miR-4795-3p	99.3206	NM_001145811
SOX6	hsa-miR-1206	99.2952	NM_001145811
SOX6	hsa-miR-19b-3p	99.0456	NM_001145811
SOX6	hsa-miR-19a-3p	99.0456	NM_001145811
SOX6	hsa-miR-548aj-3p	98.7417	NM_001145811
SOX6	hsa-miR-548x-3p	98.7417	NM_001145811
SOX6	hsa-miR-338-5p	98.5831	NM_001145811
SOX6	hsa-miR-1299	98.5715	NM_001145811
SOX6	hsa-miR-3617-5p	98.3676	NM_001145811
SOX6	hsa-miR-641	98.3676	NM_001145811
SOX6	hsa-miR-548aq-3p	98.3453	NM_001145811
SOX6	hsa-miR-548ae-3p	98.3453	NM_001145811
SOX6	hsa-miR-1827	98.3449	NM_001145811
SOX6	hsa-miR-12133	98.2965	NM_001145811
SOX6	hsa-miR-96-5p	98.2127	NM_001145811
SOX6	hsa-miR-1252-3p	98.121	NM_001145811
SOX6	hsa-miR-1271-5p	98.0871	NM_001145811
SOX6	hsa-miR-548j-3p	98.076	NM_001145811
SOX6	hsa-miR-548am-3p	98.076	NM_001145811
SOX6	hsa-miR-548ah-3p	98.076	NM_001145811
SOX6	hsa-miR-6766-3p	98.0535	NM_001145811
SOX6	hsa-miR-219a-5p	98.0535	NM_001145811
SOX6	hsa-miR-4782-3p	98.0535	NM_001145811
SOX6	hsa-miR-875-3p	97.7925	NM_001145811
SOX6	hsa-miR-302d-5p	97.4184	NM_001145811
SOX6	hsa-miR-4432	97.4061	NM_001145811
SOX6	hsa-miR-126-5p	97.2936	NM_001145811
SOX6	hsa-miR-181a-2-3p	97.1556	NM_001145811
SOX6	hsa-miR-7154-5p	97.084	NM_001145811
SOX6	hsa-miR-6511a-5p	97.0028	NM_001145811
SOX6	hsa-miR-302b-5p	96.8551	NM_001145811
SOX6	hsa-miR-6071	96.6042	NM_001145811
SOX6	hsa-miR-1910-3p	96.5728	NM_001145811
SOX6	hsa-miR-4426	96.2664	NM_001145811
SOX6	hsa-miR-3680-3p	96.0494	NM_001145811
SOX6	hsa-miR-449c-5p	95.3646	NM_001145811
SOX6	hsa-miR-34b-5p	95.3646	NM_001145811
SOX6	hsa-miR-548aw	95.3534	NM_001145811
SOX6	hsa-miR-1910-5p	95.3052	NM_001145811
SOX6	hsa-miR-4433b-5p	95.1189	NM_001145811
SOX6	hsa-miR-3622b-5p	94.6174	NM_001145811
SOX6	hsa-miR-6124	94.6096	NM_001145811
SOX6	hsa-miR-208b-3p	94.5271	NM_001145811
SOX6	hsa-miR-208a-3p	94.5271	NM_001145811

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Motifs and transcription factors (TFs) regulating SOX6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SOX6	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SOX6	metacluster_141.4	GLIS2 (directAnnotation).
SOX6	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
SOX6	metacluster_101.3	MYB (directAnnotation).
SOX6	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
SOX6	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
SOX6	metacluster_172.6	CHD2; E2F1 (directAnnotation).
SOX6	cisbp__M02645	ETS1 (directAnnotation).
SOX6	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
SOX6	hdpi__TIMELESS	TIMELESS (directAnnotation).
SOX6	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SOX6	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
SOX6	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
SOX6	transfac_pro__M06404	ZNF497 (directAnnotation).
SOX6	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
SOX6	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
SOX6	taipale_tf_pairs__GCM1_FIGLA_CASSTGNNNNNNNNNNTGCGGG_CAP_repr	FIGLA; GCM1 (directAnnotation).
SOX6	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SOX6	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."