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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: SOX13

Summary for SOX13

Gene informationGene symbol

SOX13

Ensembl ID

ENSG00000143842

Entrez ID

9580

Gene nameSRY-box transcription factor 13
SynonymsICA12|MGC117216|Sox-13
Gene typeprotein_coding
UniProtAcc

Q9UN79


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Dataset with differentially expressed gene: SOX13

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells-0.3324220.00e+00

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Expression of SOX13 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to SOX13

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SOX13

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
SOX13hsa-miR-4728-5p98.5617NM_005686
SOX13hsa-miR-430698.2324NM_005686
SOX13hsa-miR-6785-5p97.6356NM_005686
SOX13hsa-miR-464497.3524NM_005686
SOX13hsa-miR-185-5p97.3524NM_005686
SOX13hsa-miR-149-3p97.2038NM_005686
SOX13hsa-miR-6883-5p97.2038NM_005686
SOX13hsa-miR-61094.0161NM_005686
SOX13hsa-miR-624-5p88.7648NM_005686
SOX13hsa-miR-570-3p87.7939NM_005686
SOX13hsa-miR-6721-5p86.9819NM_005686
SOX13hsa-miR-6810-5p84.7712NM_005686
SOX13hsa-miR-4723-5p84.649NM_005686
SOX13hsa-miR-6870-5p84.649NM_005686
SOX13hsa-miR-7111-5p84.649NM_005686
SOX13hsa-miR-569884.649NM_005686
SOX13hsa-miR-30d-5p84.4817NM_005686
SOX13hsa-miR-30c-5p84.4817NM_005686
SOX13hsa-miR-30a-5p84.4817NM_005686
SOX13hsa-miR-30b-5p84.4817NM_005686
SOX13hsa-miR-30e-5p84.4817NM_005686
SOX13hsa-miR-495-3p81.4166NM_005686
SOX13hsa-miR-311681.0429NM_005686
SOX13hsa-miR-473980.9552NM_005686
SOX13hsa-miR-426180.8151NM_005686
SOX13hsa-miR-4756-5p80.76NM_005686
SOX13hsa-miR-132180.76NM_005686
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Motifs and transcription factors (TFs) regulating SOX13

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
SOX13metacluster_151.2ZNF23 (directAnnotation).
SOX13metacluster_144.3ZNF704; ZNF704 (directAnnotation).
SOX13homer__TWVGGTCCGC_HINFPHINFP (directAnnotation).
SOX13jaspar__MA0079.5SP1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."