Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SOX11

Summary for SOX11

Gene information	Gene symbol	SOX11
	Ensembl ID	ENSG00000176887
	Entrez ID	6664
	Gene name	SRY-box transcription factor 11
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P35716

Top

Dataset with differentially expressed gene: SOX11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.321688	2.78e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.716831	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.39959	0.00e+00

Top

Expression of SOX11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SOX11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SOX11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SOX11	hsa-miR-3613-3p	99.9127	NM_003108
SOX11	hsa-miR-3148	99.7164	NM_003108
SOX11	hsa-miR-6832-3p	98.4603	NM_003108
SOX11	hsa-miR-548c-3p	97.9427	NM_003108
SOX11	hsa-miR-204-5p	97.7482	NM_003108
SOX11	hsa-miR-211-5p	97.7482	NM_003108
SOX11	hsa-miR-629-3p	95.851	NM_003108
SOX11	hsa-miR-6867-3p	95.7285	NM_003108
SOX11	hsa-miR-551b-5p	95.1269	NM_003108
SOX11	hsa-miR-92b-3p	92.9002	NM_003108
SOX11	hsa-miR-92a-3p	92.9002	NM_003108
SOX11	hsa-miR-32-5p	92.9002	NM_003108
SOX11	hsa-miR-27a-3p	91.8631	NM_003108
SOX11	hsa-miR-27b-3p	91.8631	NM_003108
SOX11	hsa-miR-9985	91.8631	NM_003108
SOX11	hsa-miR-606	91.5818	NM_003108
SOX11	hsa-miR-367-3p	91.4951	NM_003108
SOX11	hsa-miR-25-3p	91.4951	NM_003108
SOX11	hsa-miR-363-3p	91.4951	NM_003108
SOX11	hsa-miR-3143	91.1257	NM_003108
SOX11	hsa-miR-1283	90.9564	NM_003108
SOX11	hsa-miR-1279	90.8875	NM_003108
SOX11	hsa-miR-1305	90.8842	NM_003108
SOX11	hsa-miR-4469	90.6091	NM_003108
SOX11	hsa-miR-3133	89.8606	NM_003108
SOX11	hsa-miR-4802-3p	89.4888	NM_003108
SOX11	hsa-let-7c-3p	89.0588	NM_003108
SOX11	hsa-miR-548g-5p	89.0296	NM_003108
SOX11	hsa-miR-548aj-5p	89.0296	NM_003108
SOX11	hsa-miR-548x-5p	89.0296	NM_003108
SOX11	hsa-miR-548f-5p	89.0296	NM_003108
SOX11	hsa-miR-137-3p	88.8096	NM_003108
SOX11	hsa-miR-212-3p	88.6701	NM_003108
SOX11	hsa-miR-132-3p	88.6701	NM_003108
SOX11	hsa-miR-4718	88.5898	NM_003108
SOX11	hsa-miR-4760-5p	88.3989	NM_003108
SOX11	hsa-miR-922	88.2939	NM_003108
SOX11	hsa-miR-1470	88.1033	NM_003108
SOX11	hsa-miR-5007-5p	87.3554	NM_003108
SOX11	hsa-miR-4797-3p	87.1783	NM_003108
SOX11	hsa-miR-8061	86.9226	NM_003108
SOX11	hsa-miR-4738-3p	86.6381	NM_003108
SOX11	hsa-miR-500a-5p	86.007	NM_003108
SOX11	hsa-miR-6733-3p	85.8484	NM_003108
SOX11	hsa-miR-7113-3p	85.7376	NM_003108
SOX11	hsa-miR-6887-3p	85.7113	NM_003108
SOX11	hsa-miR-145-5p	84.6866	NM_003108
SOX11	hsa-miR-5195-3p	84.6866	NM_003108
SOX11	hsa-miR-4287	84.1247	NM_003108
SOX11	hsa-miR-4685-3p	84.1247	NM_003108

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating SOX11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SOX11	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SOX11	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SOX11	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
SOX11	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SOX11	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SOX11	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
SOX11	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SOX11	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
SOX11	metacluster_3.14	WT1; WT1 (directAnnotation).
SOX11	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SOX11	cisbp__M07938	E2F1 (directAnnotation).
SOX11	transfac_pro__M05481	ZNF202 (directAnnotation).
SOX11	transfac_pro__M05298	OVOL3 (directAnnotation).
SOX11	transfac_pro__M05670	ZNF37A (directAnnotation).
SOX11	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
SOX11	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
SOX11	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
SOX11	jaspar__MA1596.1	ZNF460 (directAnnotation).
SOX11	metacluster_52.11	ZNF184 (directAnnotation).
SOX11	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
SOX11	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."