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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: SOX10

Summary for SOX10

Gene information	Gene symbol	SOX10
	Ensembl ID	ENSG00000100146
	Entrez ID	6663
	Gene name	SRY-box transcription factor 10
	Synonyms	DOM\|SOX-10\|WS2E\|WS4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SOX10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	-0.360419	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.74235	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.496908	0.00e+00

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Expression of SOX10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SOX10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SOX10	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SOX10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SOX10	hsa-miR-6783-3p	97.8323	NM_006941
SOX10	hsa-miR-1343-3p	96.8698	NM_006941
SOX10	hsa-miR-4424	93.4827	NM_006941
SOX10	hsa-miR-4677-3p	93.2631	NM_006941
SOX10	hsa-miR-486-3p	92.7158	NM_006941
SOX10	hsa-miR-6085	89.3495	NM_006941
SOX10	hsa-miR-6813-5p	89.3408	NM_006941
SOX10	hsa-miR-6735-5p	89.2458	NM_006941
SOX10	hsa-miR-6789-5p	88.8452	NM_006941
SOX10	hsa-miR-6852-5p	88.7681	NM_006941
SOX10	hsa-miR-7843-5p	88.6453	NM_006941
SOX10	hsa-miR-4775	86.9771	NM_006941
SOX10	hsa-miR-4632-5p	86.1213	NM_006941
SOX10	hsa-miR-4436b-3p	85.9857	NM_006941
SOX10	hsa-miR-6879-5p	85.9857	NM_006941
SOX10	hsa-miR-4688	85.9389	NM_006941
SOX10	hsa-miR-637	85.7549	NM_006941
SOX10	hsa-miR-4657	85.6708	NM_006941
SOX10	hsa-miR-4491	85.6708	NM_006941
SOX10	hsa-miR-939-3p	84.1261	NM_006941
SOX10	hsa-miR-6742-3p	83.9169	NM_006941
SOX10	hsa-miR-590-3p	83.2937	NM_006941
SOX10	hsa-miR-185-3p	82.831	NM_006941
SOX10	hsa-miR-6864-5p	82.5078	NM_006941

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Motifs and transcription factors (TFs) regulating SOX10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SOX10	transfac_public__M00024	E2F1 (directAnnotation).
SOX10	transfac_public__M00040	ATF2 (directAnnotation).
SOX10	metacluster_27.20	ZNF708; ZNF787; ZNF787; ZNF85 (directAnnotation).
SOX10	taipale_tf_pairs__TEAD4_HOXB13_CYAATAAAATGYN_CAP_repr	HOXB13; TEAD4 (directAnnotation).
SOX10	transfac_pro__M05298	OVOL3 (directAnnotation).
SOX10	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SOX10	metacluster_161.4	LHX9 (directAnnotation).
SOX10	jaspar__MA1933.1	SREBF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
SOX10	metacluster_153.3	down	Malignant cells	GSE164897_Vem	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."