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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SORL1

Summary for SORL1

Gene information	Gene symbol	SORL1
	Ensembl ID	ENSG00000137642
	Entrez ID	6653
	Gene name	sortilin related receptor 1
	Synonyms	C11orf32\|gp250\|LR11\|LRP9\|SorLA\|SorLA-1
	Gene type	protein_coding
	UniProtAcc	Q92673

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Dataset with differentially expressed gene: SORL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.7451	1.23e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.254734	6.08e-40
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.342087	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.377796	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.29328	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.6827	2.43e-08
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.317867	6.01e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.533099	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.484602	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.883587	0.00e+00

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Expression of SORL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SORL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SORL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SORL1	hsa-miR-5190	98.8143	NM_003105
SORL1	hsa-miR-1285-5p	98.0052	NM_003105
SORL1	hsa-miR-6762-3p	96.9348	NM_003105
SORL1	hsa-miR-330-3p	96.8259	NM_003105
SORL1	hsa-miR-4276	96.65	NM_003105
SORL1	hsa-miR-4306	94.5375	NM_003105
SORL1	hsa-miR-153-3p	94.2058	NM_003105
SORL1	hsa-miR-3163	92.9512	NM_003105
SORL1	hsa-miR-3124-3p	92.3679	NM_003105
SORL1	hsa-miR-216a-3p	92.2247	NM_003105
SORL1	hsa-miR-128-3p	92.2247	NM_003105
SORL1	hsa-miR-4711-3p	91.935	NM_003105
SORL1	hsa-miR-29b-2-5p	91.7643	NM_003105
SORL1	hsa-miR-3074-3p	91.4697	NM_003105
SORL1	hsa-miR-27b-3p	91.0538	NM_003105
SORL1	hsa-miR-27a-3p	91.0538	NM_003105
SORL1	hsa-miR-9985	91.0538	NM_003105
SORL1	hsa-miR-3681-3p	90.1762	NM_003105
SORL1	hsa-miR-4672	89.6529	NM_003105
SORL1	hsa-miR-8080	89.1917	NM_003105
SORL1	hsa-miR-576-5p	89.0762	NM_003105
SORL1	hsa-miR-551b-5p	88.8125	NM_003105
SORL1	hsa-miR-431-5p	88.7999	NM_003105
SORL1	hsa-miR-342-3p	88.6218	NM_003105
SORL1	hsa-miR-185-5p	88.5534	NM_003105
SORL1	hsa-miR-448	88.2247	NM_003105
SORL1	hsa-miR-4291	87.7764	NM_003105
SORL1	hsa-miR-548c-3p	87.1485	NM_003105
SORL1	hsa-miR-3182	86.8265	NM_003105
SORL1	hsa-miR-4644	86.7646	NM_003105
SORL1	hsa-miR-6127	86.2153	NM_003105
SORL1	hsa-miR-6133	86.2153	NM_003105
SORL1	hsa-miR-4510	86.2153	NM_003105
SORL1	hsa-miR-6129	86.2153	NM_003105
SORL1	hsa-miR-6130	86.2153	NM_003105
SORL1	hsa-miR-767-3p	85.9704	NM_003105
SORL1	hsa-miR-520d-5p	85.8016	NM_003105
SORL1	hsa-miR-524-5p	85.8016	NM_003105
SORL1	hsa-miR-466	85.6354	NM_003105
SORL1	hsa-miR-659-3p	85.2331	NM_003105
SORL1	hsa-miR-6721-5p	85.0857	NM_003105
SORL1	hsa-miR-4801	84.3387	NM_003105
SORL1	hsa-miR-12131	84.2403	NM_003105
SORL1	hsa-miR-4694-3p	84.2153	NM_003105
SORL1	hsa-miR-4264	83.0976	NM_003105
SORL1	hsa-miR-526b-3p	82.4988	NM_003105
SORL1	hsa-miR-4470	82.4203	NM_003105
SORL1	hsa-miR-106b-5p	82.1676	NM_003105
SORL1	hsa-miR-20a-5p	82.1676	NM_003105
SORL1	hsa-miR-106a-5p	82.1676	NM_003105

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Motifs and transcription factors (TFs) regulating SORL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SORL1	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
SORL1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
SORL1	jaspar__MA1483.2	ELF2 (directAnnotation).
SORL1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
SORL1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SORL1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
SORL1	metacluster_55.5	ZNF541 (directAnnotation).
SORL1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
SORL1	transfac_pro__M04950	EGR1 (directAnnotation).
SORL1	transfac_pro__M06032	ZNF727 (directAnnotation).
SORL1	taipale__NR4A2_full_AGGTCANNNNNTGACCT_repr	NR4A2 (directAnnotation).
SORL1	taipale_tf_pairs__ELK1_PAX5_RSCGGAACYACGCWYSANTG_CAP_repr	ELK1; PAX5 (directAnnotation).
SORL1	transfac_pro__M06500	ZNF614 (directAnnotation).
SORL1	transfac_pro__M04844	MAX (directAnnotation).
SORL1	metacluster_13.1	ZNF7 (directAnnotation).
SORL1	taipale_tf_pairs__HOXB2_HOXB13_NNMATCACATAAAN_CAP_repr	HOXB13; HOXB2 (directAnnotation).
SORL1	transfac_pro__M05987	ZNF180 (directAnnotation).
SORL1	metacluster_22.20	MAFG (directAnnotation).
SORL1	metacluster_26.3	ZNF232 (directAnnotation).
SORL1	metacluster_62.9	POU2F2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."