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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SOCS6

Summary for SOCS6

Gene information	Gene symbol	SOCS6
	Ensembl ID	ENSG00000170677
	Entrez ID	9306
	Gene name	suppressor of cytokine signaling 6
	Synonyms	CIS4\|Cish4\|HSPC060\|SOCS4\|SSI4\|STAI4\|STATI4
	Gene type	protein_coding
	UniProtAcc	O14544

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Dataset with differentially expressed gene: SOCS6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.317692	3.26e-30

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Expression of SOCS6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SOCS6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SOCS6	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SOCS6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SOCS6	hsa-miR-4643	99.4947	NM_004232
SOCS6	hsa-miR-4789-3p	98.7594	NM_004232
SOCS6	hsa-miR-494-3p	98.6219	NM_004232
SOCS6	hsa-miR-548aj-3p	98.3591	NM_004232
SOCS6	hsa-miR-548x-3p	98.3591	NM_004232
SOCS6	hsa-miR-524-5p	98.3251	NM_004232
SOCS6	hsa-miR-520d-5p	98.3251	NM_004232
SOCS6	hsa-miR-4289	98.2631	NM_004232
SOCS6	hsa-miR-4760-3p	97.768	NM_004232
SOCS6	hsa-miR-548aq-3p	97.5975	NM_004232
SOCS6	hsa-miR-548ae-3p	97.5975	NM_004232
SOCS6	hsa-miR-548am-3p	97.5975	NM_004232
SOCS6	hsa-miR-548ah-3p	97.5975	NM_004232
SOCS6	hsa-miR-548j-3p	97.5975	NM_004232
SOCS6	hsa-miR-3941	96.7586	NM_004232
SOCS6	hsa-miR-8485	96.7542	NM_004232
SOCS6	hsa-miR-23a-3p	96.6718	NM_004232
SOCS6	hsa-miR-23c	96.6718	NM_004232
SOCS6	hsa-miR-23b-3p	96.6718	NM_004232
SOCS6	hsa-miR-466	96.4507	NM_004232
SOCS6	hsa-miR-5700	96.4166	NM_004232
SOCS6	hsa-miR-4272	96.1616	NM_004232
SOCS6	hsa-miR-548ar-3p	95.6817	NM_004232
SOCS6	hsa-miR-183-5p	95.6557	NM_004232
SOCS6	hsa-miR-1228-3p	95.5681	NM_004232
SOCS6	hsa-miR-548ac	95.2889	NM_004232
SOCS6	hsa-miR-548bb-3p	95.2889	NM_004232
SOCS6	hsa-miR-548h-3p	95.2889	NM_004232
SOCS6	hsa-miR-548d-3p	95.2889	NM_004232
SOCS6	hsa-miR-548z	95.2889	NM_004232
SOCS6	hsa-miR-4799-5p	94.8319	NM_004232
SOCS6	hsa-miR-1298-5p	94.2854	NM_004232
SOCS6	hsa-miR-7849-3p	93.8549	NM_004232
SOCS6	hsa-miR-8070	93.7169	NM_004232
SOCS6	hsa-miR-548b-3p	93.5138	NM_004232
SOCS6	hsa-miR-548c-3p	93.3982	NM_004232
SOCS6	hsa-miR-6832-3p	93.3323	NM_004232
SOCS6	hsa-miR-12136	93.2585	NM_004232
SOCS6	hsa-miR-16-5p	92.5838	NM_004232
SOCS6	hsa-miR-15b-5p	92.5838	NM_004232
SOCS6	hsa-miR-195-5p	92.5838	NM_004232
SOCS6	hsa-miR-15a-5p	92.5838	NM_004232
SOCS6	hsa-miR-548l	92.5347	NM_004232
SOCS6	hsa-miR-4680-3p	92.2825	NM_004232
SOCS6	hsa-miR-548g-3p	92.0241	NM_004232
SOCS6	hsa-miR-15a-3p	91.8035	NM_004232
SOCS6	hsa-miR-885-3p	91.7998	NM_004232
SOCS6	hsa-miR-545-3p	91.1887	NM_004232
SOCS6	hsa-miR-4666a-3p	90.9009	NM_004232
SOCS6	hsa-miR-548a-3p	90.5119	NM_004232

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Motifs and transcription factors (TFs) regulating SOCS6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SOCS6	metacluster_135.11	NR2C2 (directAnnotation).
SOCS6	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SOCS6	tfdimers__MD00038	TFAP2C (directAnnotation).
SOCS6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SOCS6	metacluster_7.13	ZFX (directAnnotation).
SOCS6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SOCS6	cisbp__M00968	MTF2 (directAnnotation).
SOCS6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SOCS6	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SOCS6	cisbp__M00341	PAX6 (directAnnotation).
SOCS6	metacluster_198.3	ZFP64 (directAnnotation).
SOCS6	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SOCS6	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SOCS6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SOCS6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SOCS6	cisbp__M00788	ZFY (inferredBy_Orthology).
SOCS6	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SOCS6	metacluster_175.1	ZNF283 (directAnnotation).
SOCS6	hdpi__ZNF304	ZNF304 (directAnnotation).
SOCS6	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SOCS6	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SOCS6	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SOCS6	transfac_pro__M01199	TRIM28 (directAnnotation).
SOCS6	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SOCS6	metacluster_151.2	ZNF23 (directAnnotation).
SOCS6	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SOCS6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SOCS6	transfac_pro__M03806	ZBTB7C (directAnnotation).
SOCS6	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."