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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SOCS4

Summary for SOCS4

Gene information	Gene symbol	SOCS4
	Ensembl ID	ENSG00000180008
	Entrez ID	122809
	Gene name	suppressor of cytokine signaling 4
	Synonyms	SOCS7
	Gene type	protein_coding
	UniProtAcc	Q8WXH5

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Dataset with differentially expressed gene: SOCS4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.297763	1.95e-31

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Expression of SOCS4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SOCS4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SOCS4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SOCS4	hsa-miR-3646	95.9123	NM_080867
SOCS4	hsa-miR-4500	95.8021	NM_080867
SOCS4	hsa-miR-4477b	95.1418	NM_080867
SOCS4	hsa-miR-3163	95.0774	NM_080867
SOCS4	hsa-miR-506-5p	94.2527	NM_080867
SOCS4	hsa-miR-568	93.8319	NM_199421
SOCS4	hsa-miR-944	91.4388	NM_080867
SOCS4	hsa-let-7g-5p	91.3629	NM_080867
SOCS4	hsa-let-7a-5p	91.3629	NM_080867
SOCS4	hsa-let-7b-5p	91.3629	NM_080867
SOCS4	hsa-miR-98-5p	91.3629	NM_080867
SOCS4	hsa-let-7f-5p	91.3629	NM_080867
SOCS4	hsa-let-7e-5p	91.3629	NM_080867
SOCS4	hsa-let-7c-5p	91.3629	NM_080867
SOCS4	hsa-let-7i-5p	91.3629	NM_080867
SOCS4	hsa-miR-5197-3p	91.13	NM_199421
SOCS4	hsa-miR-12124	90.9788	NM_080867
SOCS4	hsa-miR-5680	90.7496	NM_199421
SOCS4	hsa-miR-12136	90.3979	NM_080867
SOCS4	hsa-miR-651-3p	90.0759	NM_199421
SOCS4	hsa-miR-183-3p	90.073	NM_080867
SOCS4	hsa-miR-4762-3p	89.9691	NM_080867
SOCS4	hsa-miR-1290	89.4855	NM_080867
SOCS4	hsa-miR-3674	89.206	NM_199421
SOCS4	hsa-let-7d-5p	88.7909	NM_080867
SOCS4	hsa-miR-4458	88.7909	NM_080867
SOCS4	hsa-miR-607	87.3351	NM_080867
SOCS4	hsa-miR-541-5p	86.8745	NM_199421
SOCS4	hsa-miR-590-3p	86.8701	NM_199421
SOCS4	hsa-miR-548c-3p	85.5237	NM_199421
SOCS4	hsa-miR-12120	85.3575	NM_199421
SOCS4	hsa-miR-2909	85.1246	NM_199421
SOCS4	hsa-miR-656-3p	84.8637	NM_199421
SOCS4	hsa-miR-4729	84.5799	NM_199421
SOCS4	hsa-miR-2052	83.8413	NM_199421
SOCS4	hsa-miR-6074	83.5267	NM_199421
SOCS4	hsa-miR-7154-5p	83.0954	NM_080867
SOCS4	hsa-miR-627-3p	82.6476	NM_080867
SOCS4	hsa-miR-138-1-3p	82.1834	NM_080867
SOCS4	hsa-miR-186-5p	81.5322	NM_199421
SOCS4	hsa-miR-3679-3p	81.4977	NM_199421
SOCS4	hsa-miR-3116	81.4058	NM_199421
SOCS4	hsa-miR-9-3p	81.2774	NM_199421
SOCS4	hsa-miR-6876-5p	81.0903	NM_080867
SOCS4	hsa-miR-4476	81.0903	NM_080867
SOCS4	hsa-miR-3662	80.8862	NM_080867
SOCS4	hsa-miR-4755-5p	80.2804	NM_080867
SOCS4	hsa-miR-5006-3p	80.2804	NM_080867
SOCS4	hsa-miR-5011-5p	80.1833	NM_199421

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Motifs and transcription factors (TFs) regulating SOCS4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SOCS4	metacluster_135.11	NR2C2 (directAnnotation).
SOCS4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SOCS4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SOCS4	metacluster_7.13	ZFX (directAnnotation).
SOCS4	cisbp__M00968	MTF2 (directAnnotation).
SOCS4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SOCS4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SOCS4	cisbp__M00341	PAX6 (directAnnotation).
SOCS4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SOCS4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SOCS4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SOCS4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SOCS4	cisbp__M00788	ZFY (inferredBy_Orthology).
SOCS4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SOCS4	metacluster_175.1	ZNF283 (directAnnotation).
SOCS4	hdpi__ZNF304	ZNF304 (directAnnotation).
SOCS4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SOCS4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SOCS4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SOCS4	transfac_pro__M01199	TRIM28 (directAnnotation).
SOCS4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SOCS4	metacluster_151.2	ZNF23 (directAnnotation).
SOCS4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SOCS4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SOCS4	transfac_pro__M03806	ZBTB7C (directAnnotation).
SOCS4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."