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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SOAT1

Summary for SOAT1

Gene information	Gene symbol	SOAT1
	Ensembl ID	ENSG00000057252
	Entrez ID	6646
	Gene name	sterol O-acyltransferase 1
	Synonyms	ACAT\|ACAT1\|SOAT\|STAT
	Gene type	protein_coding
	UniProtAcc	P35610

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Dataset with differentially expressed gene: SOAT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.488002	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.780499	0.00e+00

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Expression of SOAT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SOAT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SOAT1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SOAT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SOAT1	hsa-miR-548aj-3p	95.4141	NM_003101
SOAT1	hsa-miR-548x-3p	95.4141	NM_003101
SOAT1	hsa-miR-141-5p	94.3591	NM_003101
SOAT1	hsa-miR-548ae-3p	94.3057	NM_003101
SOAT1	hsa-miR-548aq-3p	94.3057	NM_003101
SOAT1	hsa-miR-495-3p	93.699	NM_003101
SOAT1	hsa-miR-5688	93.6633	NM_003101
SOAT1	hsa-miR-548j-3p	93.6016	NM_003101
SOAT1	hsa-miR-548ah-3p	93.6016	NM_003101
SOAT1	hsa-miR-548am-3p	93.6016	NM_003101
SOAT1	hsa-miR-7852-3p	92.9857	NM_003101
SOAT1	hsa-miR-3613-3p	91.9349	NM_003101
SOAT1	hsa-miR-548z	90.1566	NM_003101
SOAT1	hsa-miR-548h-3p	90.1566	NM_003101
SOAT1	hsa-miR-548ac	90.1566	NM_003101
SOAT1	hsa-miR-520f-5p	88.9687	NM_003101
SOAT1	hsa-miR-548bb-3p	88.9395	NM_003101
SOAT1	hsa-miR-548d-3p	88.9395	NM_003101
SOAT1	hsa-miR-373-5p	88.3481	NM_003101
SOAT1	hsa-miR-616-5p	88.3481	NM_003101
SOAT1	hsa-miR-371b-5p	88.3481	NM_003101
SOAT1	hsa-miR-548p	86.8609	NM_001252511
SOAT1	hsa-miR-5692a	86.3616	NM_003101
SOAT1	hsa-miR-651-3p	86.2439	NM_003101
SOAT1	hsa-miR-320a-3p	86.0657	NM_003101
SOAT1	hsa-miR-320c	86.0657	NM_003101
SOAT1	hsa-miR-320d	86.0657	NM_003101
SOAT1	hsa-miR-320b	86.0657	NM_003101
SOAT1	hsa-miR-4429	86.0657	NM_003101
SOAT1	hsa-miR-4758-5p	85.6674	NM_003101
SOAT1	hsa-miR-1238-5p	85.6674	NM_003101
SOAT1	hsa-miR-3658	84.2455	NM_003101
SOAT1	hsa-miR-190b-3p	83.7862	NM_003101
SOAT1	hsa-miR-4758-3p	82.8539	NM_003101
SOAT1	hsa-miR-3680-3p	82.7208	NM_003101
SOAT1	hsa-miR-195-3p	81.7758	NM_003101
SOAT1	hsa-miR-16-2-3p	81.7758	NM_003101
SOAT1	hsa-miR-4666a-3p	81.4088	NM_003101
SOAT1	hsa-miR-4658	80.8684	NM_003101
SOAT1	hsa-miR-6790-5p	80.8684	NM_003101
SOAT1	hsa-miR-760	80.7903	NM_003101
SOAT1	hsa-miR-5706	80.5413	NM_001252511
SOAT1	hsa-miR-4782-5p	80.5413	NM_001252511
SOAT1	hsa-miR-494-3p	80.3734	NM_003101
SOAT1	hsa-miR-6875-3p	80.3151	NM_003101

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Motifs and transcription factors (TFs) regulating SOAT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SOAT1	metacluster_7.13	ZFX (directAnnotation).
SOAT1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SOAT1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SOAT1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SOAT1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SOAT1	hdpi__ETV4	ETV4 (directAnnotation).
SOAT1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SOAT1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SOAT1	jaspar__MA0079.5	SP1 (directAnnotation).
SOAT1	transfac_pro__M01298	MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SOAT1	"Ezetimibe"	DB00973	small molecule
SOAT1	"Hesperetin"	DB01094	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."