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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SNX1

Summary for SNX1

Gene information	Gene symbol	SNX1
	Ensembl ID	ENSG00000028528
	Entrez ID	6642
	Gene name	sorting nexin 1
	Synonyms	HsT17379\|MGC8664\|SNX1A\|Vps5
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SNX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.476542	0.00e+00

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Expression of SNX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SNX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SNX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SNX1	hsa-miR-190a-3p	99.4069	NM_003099
SNX1	hsa-miR-6734-3p	99.146	NM_001242933
SNX1	hsa-miR-5011-5p	98.5905	NM_003099
SNX1	hsa-miR-4793-5p	95.9269	NM_003099
SNX1	hsa-miR-6165	95.8013	NM_148955
SNX1	hsa-miR-9851-3p	95.4212	NM_003099
SNX1	hsa-miR-6083	94.7307	NM_003099
SNX1	hsa-miR-593-5p	93.6897	NM_003099
SNX1	hsa-miR-4433a-3p	93.3698	NM_148955
SNX1	hsa-miR-6809-3p	91.6213	NM_148955
SNX1	hsa-miR-616-5p	91.6107	NM_001242933
SNX1	hsa-miR-1277-5p	91.3563	NM_003099
SNX1	hsa-miR-4753-3p	91.0705	NM_003099
SNX1	hsa-miR-190b-3p	90.3615	NM_003099
SNX1	hsa-miR-4720-3p	90.0563	NM_148955
SNX1	hsa-miR-373-5p	89.8869	NM_001242933
SNX1	hsa-miR-371b-5p	89.8869	NM_001242933
SNX1	hsa-miR-4503	89.0186	NM_001242933
SNX1	hsa-miR-6828-5p	89.0148	NM_148955
SNX1	hsa-miR-3646	88.1934	NM_148955
SNX1	hsa-miR-6849-3p	87.4104	NM_003099
SNX1	hsa-miR-10395-3p	86.893	NM_148955
SNX1	hsa-miR-6887-3p	86.7346	NM_001242933
SNX1	hsa-miR-767-5p	86.6634	NM_003099
SNX1	hsa-miR-4768-3p	85.4572	NM_148955
SNX1	hsa-miR-3611	84.9632	NM_148955
SNX1	hsa-miR-4804-3p	84.7475	NM_148955
SNX1	hsa-miR-4722-5p	83.8631	NM_001242933
SNX1	hsa-miR-671-5p	83.53	NM_148955
SNX1	hsa-miR-142-5p	83.2282	NM_001242933
SNX1	hsa-miR-5590-3p	83.2282	NM_001242933
SNX1	hsa-miR-522-3p	83.1966	NM_001242933
SNX1	hsa-miR-224-3p	83.1966	NM_001242933
SNX1	hsa-miR-6844	82.7211	NM_001242933
SNX1	hsa-miR-6885-3p	82.2614	NM_148955
SNX1	hsa-miR-6829-3p	82.19	NM_003099
SNX1	hsa-miR-6791-3p	82.19	NM_003099
SNX1	hsa-miR-4268	82.1603	NM_001242933
SNX1	hsa-miR-29b-2-5p	81.3854	NM_001242933
SNX1	hsa-miR-6826-3p	81.1572	NM_003099
SNX1	hsa-miR-330-3p	81.0901	NM_001242933
SNX1	hsa-miR-136-5p	80.2403	NM_001242933

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Motifs and transcription factors (TFs) regulating SNX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SNX1	metacluster_135.11	NR2C2 (directAnnotation).
SNX1	cisbp__M00341	PAX6 (directAnnotation).
SNX1	metacluster_198.3	ZFP64 (directAnnotation).
SNX1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SNX1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SNX1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."